{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T08:48:20Z","timestamp":1787042900625,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Minimally invasive parathyroid carcinoma (MIPC) is clinically and biochemically comparable with parathyroid adenoma (PA) though histopathologically differ from PA. MIPC is an intermediate of PA and parathyroid carcinoma (PC). In literature, there is no definite criterion to diagnose MIPC. Our aim was to evaluate and characterize the imaging and biochemical parameters with histological characteristics of MIPC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>\n                      Ten patients with MIPC were recruited from (single centre) Indian PHPT registry (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.indianphptregistry.com\">www.indianphptregistry.com<\/jats:ext-link>\n                      ) from January 2014 to July 2018. Clinical, biochemical, imaging and histological features of MIPC patients were reviewed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of MIPC patients (n\u00a0=\u00a010; 3 males) was 39.9\u00a0\u00b1\u00a011.3\u00a0years (range: 17\u201050). All patients had an elevated preoperative parathyroid hormone (iPTH) level ranging from 427 to 2138\u00a0pg\/mL (median: 1328). MIBI scan showed intensely avid and enlarged parathyroid tumours in all patients; LIPT in 6, RIPT in 3 and ectopic mediastinal in 1 with mean size of the tumours was 2.8\u00a0\u00b1\u00a01.1\u00a0cm. The mean of maximum standardized uptake value (SUVmax) of MIPC in F\u201018 fluorocholine PET\/CT was 6.7\u00a0\u00b1\u00a01.1 (range 6.0\u20108.3). The mean tumour weight was 12\u00a0\u00b1\u00a09.5\u00a0g (range: 1.09\u201028). All MIPC patients had identified capsular invasion in 80% and vascular invasion in 50% only but there was no local invasion, lymph nodal or distant metastasis. The mean Ki\u201067 labelling index was 3.2\u00a0\u00b1\u00a02.7 (range 1.1\u201010).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study concluded that MIPC patients are less aggressive (on the basis of imaging and histopathological findings) and should be differentiated from parathyroid\u00a0adenoma\u00a0and\u00a0carcinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14088","type":"journal-article","created":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T11:34:20Z","timestamp":1567510460000},"page":"842-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Minimally invasive parathyroid carcinoma\u2014A missing entity between parathyroid adenoma and carcinoma: Scintigraphic and histological features"],"prefix":"10.1111","volume":"91","author":[{"given":"Priyanka","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelvin Kumar","family":"Vadi","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwani","family":"Sood","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of General Surgery Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashutosh Kumar","family":"Arya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunanshu","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of General Surgery Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sapara Mohin","family":"Arvindkumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-8778","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Postgraduate Institute of Medical Education and Research (PGIMER) Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"184","article-title":"Primary hyperparathyroidism: Update on presentation, diagnosis, and management in primary care","volume":"57","author":"Pallan S","year":"2011","journal-title":"Can Fam Physician"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-017-0833-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(18)30242-4"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-3919.202234"},{"key":"e_1_2_9_6_1","first-page":"39","article-title":"Diagnostic and prognostic implications of parafibromin immunohistochemistry in parathyroid carcinomaT","author":"Pyo JS","year":"2019","journal-title":"Biosci Rep"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03515.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000313480607200511"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijnm.IJNM_44_17"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1385\/EP:16:1:049"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-014-2700-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5570"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-014-2837-0"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001701"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000001845"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10354-018-0660-0"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1414-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.6.5.385"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-012-0528-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"72","DOI":"10.32471\/exp-oncology.2312-8852.vol-41-no-1.12775","article-title":"Parathyroid carcinoma: a case report","volume":"41","author":"Tkachenko R","year":"2019","journal-title":"Exp Oncol"},{"key":"e_1_2_9_21_1","first-page":"295","article-title":"Parathyroid carcinoma. A single Institution experience and a review of the international literature","volume":"89","author":"Quaglino F","year":"2018","journal-title":"Ann Ital Chir"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-0366-5"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12761"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/921814"},{"key":"e_1_2_9_25_1","first-page":"279","article-title":"Effect of gender, biochemical parameters & parathyroid surgery on gastrointestinal manifestations of symptomatic primary hyperparathyroidism","volume":"139","author":"Shah VN","year":"2014","journal-title":"Indian J Med Res"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197303)31:3<600::AID-CNCR2820310316>3.0.CO;2-0"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199308000-00007"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.133"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3771-z"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.08.052"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-016-9426-7"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2010.04.007"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.10.013"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.8.866"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14088","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14088","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:27:54Z","timestamp":1694197674000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,3]]},"references-count":33,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/cen.14088"],"URL":"https:\/\/doi.org\/10.1111\/cen.14088","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,3]]},"assertion":[{"value":"2019-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}