{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:07:00Z","timestamp":1790078820588,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Summary<\/jats:title><jats:p>Interferon (IFN)\u2010\u03b1 treatment predisposes patients to the occurrence of autoimmune thyroid disease (AITD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated associations of single nucleotide polymorphisms (SNPs) of molecules participating in the IFN\u2010\u03b1 signature, including rs2304204 and rs2304206 of IFN regulatory factor 3 (IRF3), rs1061501 of IRF7, and rs7708392 of TNFA1P3\u2010interacting protein 1 with serum IFN\u2010\u03b1 levels and AITD in an ethnic Chinese (ie Taiwanese) population. Totally, 319 patients with Graves' disease (GD), 83 patients with Hashimoto's thyroiditis (HT) and 351 healthy controls were recruited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were increased percentages of the C allele, and CC and TC\u00a0+\u00a0CC genotypes of rs1061501 in GD patients compared to the controls. HT patients had higher serum IFN\u2010\u03b1 levels compared to the controls, while there was no difference in serum IFN\u2010\u03b1 levels between patients with GD and controls. However, patients with GD in a remission status had lower serum IFN\u2010\u03b1 levels than those without remission. On the other hand, the C allele of rs1061501 was only associated with serum IFN\u2010\u03b1 levels in patients with HT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SNP rs1061501 of IRF7 was associated with the development of GD. Serum IFN\u2010\u03b1 levels were associated with HT, while they might modify the disease status of GD. Moreover, a genetic effect of rs1061501 on regulating serum IFN\u2010\u03b1 production was observed in HT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14090","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T10:24:55Z","timestamp":1567938295000},"page":"860-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of gene polymorphisms in interferon\u2010alpha signature\u2010related genes with autoimmune thyroid diseases"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9444-8249","authenticated-orcid":false,"given":"Jiunn\u2010Diann","family":"Lin","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine Shuang Ho Hospital Taipei Medical University New Taipei City Taiwan"},{"name":"Division of Endocrinology and Metabolism Department of Internal Medicine School of Medicine College of Medicine 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