{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:47:14Z","timestamp":1772110034271,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Growth hormone treatment increases glomerular filtration rate (GFR), as serum IGF\u2010I stimulates the renin\u2010angiotensin system. Infants born with a low birth weight have a smaller number of nephrons, which cause a lower GFR, a higher blood pressure and a higher albumin\u2010to\u2010creatinine ratio in early adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 261 young adults born SGA, previously treated with growth hormone (SGA\u2010GH), were longitudinally followed. Glomerular filtration rate, based on serum creatinine levels, was determined at cessation of GH treatment and at 6\u00a0months, 2\u00a0years and 5\u00a0years thereafter. Glomerular filtration rate, blood pressure and urinary albumin\u2010to\u2010creatinine ratio at 5\u00a0years after cessation of GH were compared with untreated age\u2010matched controls (56 untreated short subjects born SGA [SGA\u2010S], 118 subjects born SGA with spontaneous catch\u2010up growth [SGA\u2010CU], 135 subjects born appropriate for gestational age [AGA]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Glomerular filtration rate decreased significantly only during the first 6\u00a0months after cessation of GH treatment, while remaining well within the normal range (124.6 vs 120.2\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). SGA\u2010GH adults had a similar GFR, blood pressure and urinary albumin\u2010to\u2010creatinine ratio as the healthy controls born SGA and AGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, our 5\u00a0years longitudinal follow\u2010up study shows a decrease in GFR during 6\u00a0months after GH cessation, but thereafter GFR remained stable and within the normal range. Glomerular filtration rate, blood pressure and urinary albumin\u2010to\u2010creatinine ratio at 21\u00a0years of age were similar in GH\u2010treated young adults born SGA and untreated controls born SGA or AGA. We conclude that long\u2010term GH treatment in children born SGA has no unfavourable effects on kidney function in early adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Pr\u00e9cis<\/jats:title><jats:p>We present a longitudinal study on kidney function in the follow\u2010up of growth hormone\u2010treated young adults who were born small for gestational age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14095","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T10:04:11Z","timestamp":1568282651000},"page":"892-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glomerular filtration rate, blood pressure and microalbuminuria in adults born SGA: A 5\u2010year longitudinal study after cessation of GH treatment"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1990-1090","authenticated-orcid":false,"given":"Wesley J.","family":"Goedegebuure","sequence":"first","affiliation":[{"name":"Department of Paediatrics Subdivision of Endocrinology Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerthe F.","family":"Kerkhof","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Subdivision of Endocrinology Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita C. S.","family":"Hokken\u2010Koelega","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Subdivision of Endocrinology Erasmus University Medical Centre Rotterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000148716.71231.81"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021172"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0293"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.05.024"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339911794273900"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1071"},{"issue":"5","key":"e_1_2_8_9_1","first-page":"423","article-title":"Growth hormone, the insulin\u2010like growth factor system, and the kidney","volume":"17","author":"Feld S","year":"1996","journal-title":"Endocr Rev"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2013.875834"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2011.08.001"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09741110"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60674-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00040-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.12.003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2010.01306.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00018.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80967-X"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.09.013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007020252"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-005-1828-6"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.06.015"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.03.048"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.761"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200003000-00006"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(69)80224-6"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80382-8"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g4507"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852873"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92465-1"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000046091"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-003-3029-2"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30311-X"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)30422-3"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:28:09Z","timestamp":1694212089000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,30]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/cen.14095"],"URL":"https:\/\/doi.org\/10.1111\/cen.14095","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,30]]},"assertion":[{"value":"2019-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}