{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:54:44Z","timestamp":1761519284327,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess a possible relationship between maternal cognitive dysfunction during pregnancy and hypothyroxinemia, adjusted for major confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Thyroid dysfunction in general is associated with cognitive dysfunction. Cognitive dysfunction is common during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective follow\u2010up study from 12 to 32\u00a0weeks of pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>2082 healthy pregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Cognitive function, depression and sleeping problems were assessed by self\u2010report questionnaires at 12, 22 and 32\u00a0weeks of gestation, higher scores reflecting more symptoms. FT4, TSH and TPO\u2010Ab were assessed at 12\u00a0weeks of gestation.<\/jats:p><jats:p>Definitions: healthy (euthyroxinemia) control group: FT4 within 10\u201090th percentiles, without elevated TPO\u2010Ab titres and TSH within first trimester\u2010specific reference range (0.23\u20104.0\u00a0mU\/L). Hypothyroxinemia: FT4 &lt;2.5th percentile with TSH within first trimester\u2010specific reference range. Poor cognitive function: a score &gt;1 SD\u00a0&gt;\u00a0mean on the cognitive function scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 54 women showed hypothyroxinemia and 1476 women had euthyroxinemia. At 12\u00a0weeks, multiple logistic regression showed that poor cognitive function was independently related to hypothyroxinemia: OR: 2.9 (95% CI: 1.6\u20105.4), adjusted for depression (OR: 3.1; 95% CI: 2.7\u20104.6) and sleeping problems (OR: 2.8, 95% CI: 1.9\u20103.9). TPO\u2010Ab\u00a0+\u00a0women with hypothyroxinemia had the highest levels of cognitive dysfunction. Other cut\u2010offs of hypothyroxinemia (&lt;5th or &lt;10th percentile with normal TSH) showed similar results. GLM\u2010ANOVA showed that throughout pregnancy women with hypothyroxinemia at 12\u00a0weeks had significantly higher cognitive dysfunction scores compared with the healthy controls: <jats:italic>F<\/jats:italic>\u00a0=\u00a012.1, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Women with hypothyroxinemia during early gestation are at risk for poor cognitive function throughout gestation, adjusted for depression and sleeping problems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14107","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T22:44:59Z","timestamp":1571179499000},"page":"824-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Maternal cognitive function during pregnancy in relation to hypo\u2010 and hyperthyroxinemia"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2732-7137","authenticated-orcid":false,"given":"Victor J.","family":"Pop","sequence":"first","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad","family":"Ormindean","sequence":"additional","affiliation":[{"name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia","family":"Mocan","sequence":"additional","affiliation":[{"name":"Center for Diabetes, Nutrition and Metabolic Diseases Emergency Clinical County Hospital Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margreet","family":"Meems","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten","family":"Broeren","sequence":"additional","affiliation":[{"name":"Maxima Medical Hospital Veldhoven The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan K.","family":"Denollet","sequence":"additional","affiliation":[{"name":"Department of Medical and Clinical Psychology Tilburg University Tilburg The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilmar M.","family":"Wiersinga","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Academic Medical Center University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adomas","family":"Bunevicius","sequence":"additional","affiliation":[{"name":"Computational Neuroscience Outcomes Center Brigham and Women's Hospital Harvard Medical School Boston MA USA"},{"name":"Lithuanian University of Health Sciences Kaunas Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.3109\/01674829909075580"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.3109\/01674829909075590"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1016\/j.psyneuen.2010.01.015"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/S0306-4530(01)00003-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1186\/s12884-018-2087-4"},{"doi-asserted-by":"crossref","unstructured":"Diagnostic and Statistical Manual of Mental Disorders V (DSM\u2010V) American Psychiatric Association;2013.","key":"e_1_2_8_7_1","DOI":"10.1176\/appi.books.9780890425596"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1097\/01.AOG.0000116689.75396.5f"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1089\/10507250152741037"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1016\/S0149-7634(01)00037-9"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1007\/s12020-018-1649-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1089\/thy.2016.0457"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1038\/nrendo.2017.93"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1046\/j.1365-2265.2003.01822.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/S0140-6736(05)66489-6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1001\/jama.2019.10931"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1111\/j.1365-2826.2008.01733.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1111\/cen.13433"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1186\/1471-2393-14-312"},{"doi-asserted-by":"publisher","key":"e_1_2_8_20_1","DOI":"10.1136\/bmj.39335.541782.AD"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1192\/bjp.150.6.782"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1016\/0165-0327(96)00008-0"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1016\/0165-0327(92)90041-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1016\/j.jpsychores.2010.07.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_25_1","DOI":"10.1046\/j.1365-2265.1999.00639.x"},{"volume-title":"The handbook of psychological testing","year":"2000","author":"Kline P","key":"e_1_2_8_26_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_27_1","DOI":"10.1016\/S0306-4522(01)00541-3"},{"doi-asserted-by":"publisher","key":"e_1_2_8_28_1","DOI":"10.1016\/S0006-8993(00)03148-6"},{"issue":"2","key":"e_1_2_8_29_1","first-page":"245","article-title":"Cognitive functioning in coronary artery disease patients: associations with thyroid hormones, N\u2010terminal Pro\u2010B\u2010type natriuretic peptide and high\u2010sensitivity C\u2010reactive protein","volume":"32","author":"Burkauskas J","year":"2017","journal-title":"Arch Clin Neuropsychol"},{"doi-asserted-by":"publisher","key":"e_1_2_8_30_1","DOI":"10.1056\/NEJMoa1603825"},{"doi-asserted-by":"publisher","key":"e_1_2_8_31_1","DOI":"10.1056\/NEJMoa1106104"},{"doi-asserted-by":"publisher","key":"e_1_2_8_32_1","DOI":"10.1056\/NEJMoa1606205"},{"doi-asserted-by":"publisher","key":"e_1_2_8_33_1","DOI":"10.1210\/jc.2017-01560"},{"doi-asserted-by":"publisher","key":"e_1_2_8_34_1","DOI":"10.1016\/j.bbi.2014.03.008"},{"doi-asserted-by":"publisher","key":"e_1_2_8_35_1","DOI":"10.1097\/GME.0b013e318291f5a6"},{"doi-asserted-by":"publisher","key":"e_1_2_8_36_1","DOI":"10.1097\/gme.0b013e318241fd22"},{"doi-asserted-by":"publisher","key":"e_1_2_8_37_1","DOI":"10.1017\/S0029665118002835"},{"doi-asserted-by":"publisher","key":"e_1_2_8_38_1","DOI":"10.1007\/s12011-018-1502-z"},{"doi-asserted-by":"publisher","key":"e_1_2_8_39_1","DOI":"10.1210\/jc.2007-1082"},{"doi-asserted-by":"publisher","key":"e_1_2_8_40_1","DOI":"10.1089\/thy.2017.0491"},{"doi-asserted-by":"publisher","key":"e_1_2_8_41_1","DOI":"10.1017\/S003329171600283X"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14107","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14107","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:28:42Z","timestamp":1694212122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,6]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/cen.14107"],"URL":"https:\/\/doi.org\/10.1111\/cen.14107","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2019,11,6]]},"assertion":[{"value":"2019-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}