{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:45Z","timestamp":1787014005312,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T00:00:00Z","timestamp":1572998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Women with early\u2010onset oestrogen deficiency are at risk of reduced bone mineral density (BMD). We sought to assess fracture history and BMD in women with Turner syndrome (TS) and premature ovarian insufficiency (POI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross\u2010sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>Two hundred and sixty seven women with TS (median age 34.3\u00a0years) and 67 women with POI (median age 28.1\u00a0years).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>A questionnaire was used to collect data on fracture history, co\u2010morbidities and drug history including age at first oestrogen exposure. Clinical data included height, weight, serum vitamin D and hip and spine T\u2010scores, which were adjusted for height and age. Fractures were subdivided into major osteoporotic fractures (MOF) and \u2018other\u2019 fracture types.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall fracture rate was similar in women with TS and POI (82 [30.5%] vs 22 [32.8%] respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.74). Compared to women with POI, those with TS had more fractures at MOF sites (30.2% vs 52.7%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.012) and fewer phalangeal fractures (27.9% vs 9.8%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.005). There was no difference in BMD between women who sustained a fracture compared to those who did not. Women with TS who fractured were more likely to suffer from hearing impairment compared to those with no fracture (62.2% vs 48.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.045).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TS is not associated with an overall excess risk of bone fracture. The higher rate of fractures at MOF sites in women with TS may be secondary to hearing impairment, thin cortical bone and abnormal bone remodelling.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14110","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T21:29:54Z","timestamp":1571088594000},"page":"743-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fracture rate in women with oestrogen deficiency \u2013 Comparison of Turner syndrome and premature ovarian insufficiency"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-8153","authenticated-orcid":false,"given":"Carol","family":"Cardona Attard","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London 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S.","family":"Talaulikar","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C.","family":"Davies","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard S.","family":"Conway","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London 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