{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:44Z","timestamp":1787014004542,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T00:00:00Z","timestamp":1573516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Importance<\/jats:title>\n                    <jats:p>Guidelines advocate subtotal parathyroidectomy (SPTX) or total parathyroidectomy with autotransplantation (TPTX) with bilateral cervical thymectomy for primary hyperparathyroidism (pHPT) associated with multiple endocrine neoplasia type 1 (MEN1). However, both procedures are associated with a significant risk of permanent hypoparathyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of the current study was to compare long\u2010term results of either single gland excision (SGE, 1\u20102 glands), SPTX and TPTX for the treatment of MEN1\u2010associated pHPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design and setting<\/jats:title>\n                    <jats:p>Data of genetically confirmed MEN1 patients who underwent surgery for pHPT between 1987 and 2017 were retrieved from a prospective database and were retrospectively analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010nine MEN1 patients underwent either TPTX (n\u00a0=\u00a038, 42.7%), SPTX (n\u00a0=\u00a023, 25.8%) or SGE (n\u00a0=\u00a028, 31.5%). The rate of disease persistence after initial surgery was 2.6%, 0% and 14.2% in the TPTX, SPTX and SGE groups, respectively. After median follow\u2010up of 112 (range 7\u2010411) months, the rate of recurrent pHPT was significantly higher in the SGE group (n\u00a0=\u00a019, 21.3%) compared with the TPTX (n\u00a0=\u00a04, 4.4%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001) and the SPTX (n\u00a0=\u00a09, 10.1%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.03) groups. Analysis of the recurrence\u2010free time among the surgical groups revealed a significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.036). The median time to recurrence was significantly shorter after SGE (101, range 3\u2010301\u00a0months) than after SPTX (139, range 28\u2010278\u00a0months,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.018) and TPTX (204, range 75\u2010396\u00a0months,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.049). Twelve (32%) patients who underwent TPTX developed permanent hypoparathyroidism compared with only 4 (17%,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.06) in the SPTX and 0 in the SGE group (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Given the high rate of postoperative permanent hypoparathyroidism after TPTX and SPTX, SGE is a valid option for the treatment of MEN1\u2010associated pHPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14112","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T12:53:11Z","timestamp":1571403191000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Single gland excision for MEN1\u2010associated primary hyperparathyroidism"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-2712","authenticated-orcid":false,"given":"Jerena","family":"Manoharan","sequence":"first","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max B.","family":"Albers","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Maurer","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Mintziras","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"W\u00e4chter","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef K.","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Department of Visceral Thoracic and Vascular Surgery Philipps University Marburg Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1230"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026562217102"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0231"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-204"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3659"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3992-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4865-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7154"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2006.12.009"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-011-2092-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3624-9"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2013.03.004"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00123"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0528"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0628"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7321-8"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4366-z"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(03)00406-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-015-3297-9"},{"key":"#cr-split#-e_1_2_8_21_1.1","unstructured":"KraimpsJL DuhQY DemeureM ClarkOH. 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