{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:28:02Z","timestamp":1791228482722,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T00:00:00Z","timestamp":1573257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine basal and gonadotrophin\u2010releasing hormone analogue (GnRHa)\u2010stimulated peak luteinising hormone (LH) cut\u2010offs to diagnose onset of early or normal puberty in girls with each Tanner stage of breast (II and III).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, Patients and Measurements<\/jats:title><jats:p>A retrospective study of 601 girls with breast onset before 8\u00a0years of age who underwent GnRHa test was conducted. Patients were categorized as CPP and premature thelarche. Each group was divided into two subgroups; Tanner II and III. Cost\u2010effectiveness analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In comparison with basal LH cut\u2010off of 0.3\u00a0IU\/L, basal LH cut\u2010off of 0.2\u00a0IU\/L had comparable specificity (Tanner II: 98.0% vs 94.8%, Tanner III: 98.8% vs 93.8%), but greater sensitivity (Tanner II: 28.3% vs 41.7%, Tanner III: 45.2% vs 59.3%). Specificity of basal LH cut\u2010off of 0.2\u00a0IU\/L was not inferior to that of the traditionally used peak LH of 5\u00a0IU\/L. Using basal LH cut\u2010off of 0.2\u00a0IU\/L followed by GnRHa test in girls with negative basal LH was more cost\u2010saving when compared with using the cut\u2010off of 0.3\u00a0IU\/L. Moreover, using basal LH cut\u2010off of 0.2\u00a0IU\/L followed by GnRHa test provided a cost reduction when compared with performing GnRHa test in all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Basal serum LH cut\u2010off of 0.2\u00a0IU\/L could be a simple and cost\u2010saving tool for initial diagnosis of onset of early or normal puberty in girls with Tanner II and III before proceeding to GnRH testing.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14124","type":"journal-article","created":{"date-parts":[[2019,11,9]],"date-time":"2019-11-09T10:35:35Z","timestamp":1573295735000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Basal serum luteinising hormone cut\u2010off, and its utility and cost\u2010effectiveness for aiding the diagnosis of the onset of puberty in girls with early stages of breast development"],"prefix":"10.1111","volume":"92","author":[{"given":"Somboon","family":"Wankanit","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-2963","authenticated-orcid":false,"given":"Pat","family":"Mahachoklertwattana","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oraluck","family":"Pattanaprateep","sequence":"additional","affiliation":[{"name":"Section for Clinical Epidemiology and Biostatistics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6161-6210","authenticated-orcid":false,"given":"Preamrudee","family":"Poomthavorn","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0800459"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-017-0627-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2012.04517.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000232164"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03796.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70254-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1569"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.10.3539"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v3i1.03"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1387790"},{"key":"e_1_2_8_12_1","volume-title":"Reference for weight, height and nutritional indices in Thai aged 1 day to 19 years","author":"Department of Health, Ministry of Public Health","year":"2000"},{"key":"e_1_2_8_13_1","unstructured":"World Health Organization.Growth reference data for 5\u201019 years. 2007 WHO reference.https:\/\/www.who.int\/growthref\/en\/. 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