{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:47:36Z","timestamp":1772768856674,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,12,22]],"date-time":"2019-12-22T00:00:00Z","timestamp":1576972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Previous studies suggested that plasma aldosterone (PAC) response to ACTH stimulation could predict the subtypes of primary aldosteronism (PA) and avoid adrenal venous sampling (AVS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the usefulness of peripheral (P) PAC response to ACTH stimulation during AVS to identify the source of aldosterone in patients with PA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and fifteen patients were assigned to four different lateralization ratio (LR) groups based on different combinations of basal (\u2265 or &lt;2) and post\u2010ACTH LR (\u2265 or &lt;4). The P vein parameters analysed included as follows: mean basal PAC, maximal PAC (PAC<jats:sub>max<\/jats:sub>), and PAC\/C ratio (PAC<jats:sub>max<\/jats:sub>\/C), PAC absolute increase, PAC relative increase following ACTH bolus (250\u00a0mcg IV) and maximal variation of PAC\/C ratio between post\u2010ACTH and basal measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean basal PAC was significantly higher in group 1 (basal LR\u00a0&gt;\u00a02 and post\u2010ACTH\u00a0&gt;\u00a04) than in group 2 (basal LR\u00a0&gt;\u00a02, post\u2010ACTH\u00a0&lt;\u00a04) or group 4 (basal LR\u00a0&lt;\u00a02 post\u2010ACTH\u00a0&lt;\u00a04) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). PAC<jats:sub>max<\/jats:sub>, PAC<jats:sub>max<\/jats:sub>\/C and PAC absolute increase following ACTH were higher in group 1 than the others (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.017). Using receiver operating characteristic (ROC) curves analysis of groups 1 and 4, best AUC were obtained with mean basal PAC (AUC: 0.757 95% IC: 0.653\u20100.861), PAC<jats:sub>max<\/jats:sub> (AUC: 0.753 95% IC: 0.646\u20100.860) and PAC<jats:sub>max<\/jats:sub>\/C (AUC: 0.750 95% IC: 0.646\u20100.853).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>P mean basal PAC and PAC<jats:sub>max<\/jats:sub> and PAC<jats:sub>max<\/jats:sub>\/C are higher in basal and ACTH lateralized PA than in other groups. Peripheral PAC cut\u2010off values fail to adequately distinguish all groups and cannot replace the requirement to conduct AVS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14137","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T09:02:33Z","timestamp":1575363753000},"page":"187-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Use of peripheral plasma aldosterone concentration and response to ACTH during simultaneous bilateral adrenal veins sampling to predict the source of aldosterone secretion in primary aldosteronism"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9791-2118","authenticated-orcid":false,"given":"Matthieu","family":"St\u2010Jean","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Medicine and Research Center Centre hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM) Montr\u00e9al QC 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