{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:24:11Z","timestamp":1790346251852,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003745","name":"Stiftelserna Wilhelm och Martina Lundgrens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003745","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>68\u00a0<\/jats:sup>Ga\u2010DOTATOC PET<\/jats:styled-content> targets somatostatin receptors (SSTR<\/jats:styled-content>s) and is well established for the detection of SSTR<\/jats:styled-content>\u2010expressing tumors, such as gastrointestinal neuroendocrine tumors. Pituitary adenomas, recently designated as pituitary neuroendocrine tumors (PitNET<\/jats:styled-content>s), also express SSTR<\/jats:styled-content>s, but there has been no previous evaluations of 68\u00a0<\/jats:sup>Ga\u2010DOTATOC PET<\/jats:styled-content> in PitNET<\/jats:styled-content> patients. The aim of this pilot study was to evaluate the diagnostic properties of 68\u00a0<\/jats:sup>Ga\u2010DOTATOC PET<\/jats:styled-content> in the most common PitNET<\/jats:styled-content>, ie non\u2010functioning (NF<\/jats:styled-content>)\u2010PitNET<\/jats:styled-content>.<\/jats:p><\/jats:sec>Design\/Patients<\/jats:title>NF<\/jats:styled-content>\u2010PitNET<\/jats:styled-content> patients (n\u00a0=\u00a09) and controls (n\u00a0=\u00a013) were examined preoperatively with 68\u00a0<\/jats:sup>Ga\u2010DOTATOC PET<\/jats:styled-content> for 45\u00a0min after tracer injection in dynamic list mode. Tumor specimens were collected during surgery in patients. MRI<\/jats:styled-content> and PET<\/jats:styled-content> images were co\u2010registered using PMOD<\/jats:styled-content> software. The maximum standard uptake value (SUV<\/jats:styled-content>max<\/jats:sub>) was analyzed in manually outlined regions of interest (ROI<\/jats:styled-content>) around the tumor in patients and around the pituitary gland in controls. Immunohistochemical analyses were conducted on tumor specimens for assessment of tumor cell type and SSTR<\/jats:styled-content> expression.<\/jats:p><\/jats:sec>Results<\/jats:title>Median SUV<\/jats:styled-content>max<\/jats:sub> (IQR<\/jats:styled-content>) was lower in patients than in controls (3.9 [3.4\u20108.5] vs<\/jats:italic> 14.1 [12.5\u201015.9]; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01]. In ROC<\/jats:styled-content> analysis, the area under the curve was 0.87 (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.01) for SUV<\/jats:styled-content>max<\/jats:sub>, with 78% sensitivity and 92% specificity. Immunohistochemical analysis showed NF<\/jats:styled-content>\u2010PitNET<\/jats:styled-content>s were of gonadotroph (n\u00a0=\u00a07) and corticotroph (n\u00a0=\u00a02) origin. SSTR<\/jats:styled-content> expression was high for SSTR<\/jats:styled-content>3, low\u2010to\u2010moderate for SSTR<\/jats:styled-content>2, and low for SSTR<\/jats:styled-content>1 and SSTR<\/jats:styled-content>5.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This proof\u2010of\u2010concept study shows that 68<\/jats:sup>Ga\u2010DOTATOC PET<\/jats:styled-content> can be used to differentiate between normal pituitary tissue and NF<\/jats:styled-content>\u2010PitNET<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14144","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T10:23:39Z","timestamp":1577096619000},"page":"222-231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lower 68<\/sup>Ga\u2010DOTATOC uptake in nonfunctioning pituitary neuroendocrine tumours compared to normal pituitary gland\u2014A proof\u2010of\u2010concept study"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-7744","authenticated-orcid":false,"given":"Axel","family":"Tj\u00f6rnstrand","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"},{"name":"Department of Radiology Sahlgrenska University Hospital G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-7331","authenticated-orcid":false,"given":"Olivera","family":"Casar\u2010Borota","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology Uppsala University Uppsala Sweden"},{"name":"Department of Clinical Pathology Uppsala University Hospital Uppsala 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Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5643-3882","authenticated-orcid":false,"given":"Peter","family":"Gjertsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Sahlgrenska University Hospital G\u00f6teborg Sweden"},{"name":"Deptartment of Molecular and Clinical Medicine Institute of Medicine, at Sahlgrenska Academy University of Gothenburg G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Himmelman","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering Sahlgrenska University Hospital G\u00f6teborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksiy","family":"Itsenko","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering Sahlgrenska University Hospital G\u00f6teborg 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