{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T02:25:09Z","timestamp":1772504709168,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Primary aldosteronism (PA) is known to increase vertebral fracture (VF), although the detailed mechanism remains to be elucidated. We hypothesized that the PA subtype is associated with VF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate whether unilateral PA is associated with the prevalence of VF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective cross\u2010sectional study in a single referral centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We identified 210 hypertensive patients whose clinical data were available for case\u2010detection results. One hundred and fifty\u2010two patients were diagnosed with PA using captopril challenge tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We measured the prevalence of VF, according to PA subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred thirteen patients with PA were subtype classified by adrenal vein sampling. Of these, 37 patients had unilateral PA, 76 patients had bilateral PA, 58 patients had non\u2010PA; 39 patients with PA were not subtype\u2010classified. Patients with PA had a higher prevalence of VF (29%, 44\/152) than those with non\u2010PA (12%, 7\/58; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011). Moreover, unilateral PA had a higher prevalence of VF (46%, 17\/37) than bilateral PA (20%, 15\/76; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.021). There was no significant difference <jats:italic>in<\/jats:italic> the prevalence of VF between bilateral PA and non\u2010PA. Unilateral PA was an independent risk factor for VF after adjusting for age and sex (OR: 3.16, 95% confidence interval: 1.12\u20108.92; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.017). Among patients with unilateral PA, serum cortisol concentrations after 1\u2010mg dexamethasone suppression test were higher in those with VF (1.32\u00a0\u00b1\u00a00.67\u00a0g\/dL) than those without (0.96\u00a0\u00b1\u00a00.33\u00a0g\/dL; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.048).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Unilateral PA is an independent risk factor for VF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14145","type":"journal-article","created":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T16:54:57Z","timestamp":1577120097000},"page":"206-213","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Unilateral primary aldosteronism as an independent risk factor for vertebral fracture"],"prefix":"10.1111","volume":"92","author":[{"given":"Maki","family":"Yokomoto\u2010Umakoshi","sequence":"first","affiliation":[{"name":"Department of Medicine and Bioregulatory 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