{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:20Z","timestamp":1747183880887,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007316","name":"Division of Cancer Prevention, National Cancer Institute","doi-asserted-by":"publisher","award":["R25CA134286"],"award-info":[{"award-number":["R25CA134286"]}],"id":[{"id":"10.13039\/100007316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["P01ES11261","R01ES01575","R01ES020349","R01ES024381","R01ES025214"],"award-info":[{"award-number":["P01ES11261","R01ES01575","R01ES020349","R01ES024381","R01ES025214"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Maternal thyroid function during pregnancy may influence offspring thyroid function, though relations between maternal and child thyroid function are incompletely understood. We sought to characterize relations between maternal, cord and child thyroid hormone concentrations in a population of mother\u2010child pairs with largely normal thyroid function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a prospective birth cohort, we measured thyroid hormone concentrations in 203 mothers at 16 gestational weeks, 273 newborns and 159 children at 3\u00a0years among participants in the Health Outcomes and Measures of the Environment (HOME) Study. We used multivariable linear regression to estimate associations of maternal thyroid hormones during pregnancy with cord serum thyroid hormones and also estimated associations of maternal and cord thyroid hormones with child thyroid\u2010stimulating hormone (TSH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Each doubling of maternal TSH was associated with a 16.4% increase of newborn TSH (95% CI: 3.9%, 30.5%), and each doubling of newborn TSH concentrations was associated with a 10.4% increase in child TSH concentrations at 3\u00a0years (95% CI: 0.1%, 21.7%). An interquartile range increase in cord FT4 concentrations was associated with an 11.7% decrease in child TSH concentrations at 3\u00a0years (95% CI: \u221220.2%, \u22122.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed relationships between maternal, newborn and child thyroid hormone concentrations in the HOME Study. Our study contributes to understandings of interindividual variability in thyroid function among mother\u2010child pairs, which may inform future efforts to identify risk factors for thyroid disorders or thyroid\u2010related health outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14151","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T18:14:52Z","timestamp":1578161692000},"page":"366-372","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal, cord, and three\u2010year\u2010old child serum thyroid hormone concentrations in the Health Outcomes and Measures of the Environment study"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8172-3398","authenticated-orcid":false,"given":"Brett T.","family":"Doherty","sequence":"first","affiliation":[{"name":"Department of Epidemiology Geisel School of Medicine Dartmouth College Hanover NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6136-0286","authenticated-orcid":false,"given":"Noelle","family":"Kosarek","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Geisel School of Medicine Dartmouth College Hanover NH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-0243","authenticated-orcid":false,"given":"Andy N.","family":"Hoofnagle","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5247-3721","authenticated-orcid":false,"given":"Yingying","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of General and Community Pediatrics Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-2658","authenticated-orcid":false,"given":"R. Thomas","family":"Zoeller","sequence":"additional","affiliation":[{"name":"Department of Biology University of Massachusetts Amherst MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4458-0516","authenticated-orcid":false,"given":"Kimberly","family":"Yolton","sequence":"additional","affiliation":[{"name":"Division of General and Community Pediatrics Department of Pediatrics Cincinnati Children's Hospital Medical Center University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9713-6438","authenticated-orcid":false,"given":"Aimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Epidemiology and Biostatistics Department of Environmental Health University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce 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