{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:44Z","timestamp":1787014004588,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"Abstract<\/jats:title>\n \n Background and Objective<\/jats:title>\n \n Parathyroid carcinoma (PC) is a rare malignant neoplasm with a relatively poor prognosis. The loss of parafibromin expression or the presence of\n CDC73<\/jats:italic>\n mutation has been found to be remarkably associated with malignancy in parathyroid tumours. However, the prognostic role of them in PC has not yet been shown due to sampling limitations. We conducted a systematic review and meta\u2010analysis based on individual patient data to clarify the performance of parafibromin immunohistochemical staining and\n CDC73<\/jats:italic>\n gene sequencing in predicting outcomes for patients PC.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Published studies from PubMed\/MEDLINE, EMBASE, Cochrane and Scopus Databases were searched using the terms \u2018parafibromin\u2019, \u2018CDC73\u2019, \u2018HRPT2\u2019 and \u2018parathyroid\u2019 to identify eligible studies. From the included studies, the survival data of patients with PC were extracted, and a Cox proportional hazards model was used to assess hazard ratio (HR)\u00a0for\u00a0disease\u2010free survival (DFS) and overall survival (OS).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 193 patients from 9 studies were included in this survival analysis. Negative immunohistochemical staining of parafibromin was shown to be a risk factor for recurrence\/metastasis (HR 2.73,\n P<\/jats:italic>\n \u00a0=\u00a0.002) and death (HR 2.54,\n P<\/jats:italic>\n \u00a0=\u00a0.004). Patient age\u00a0\u2265\u00a050\u00a0years was significantly related to lower OS (HR 2.37,\n P<\/jats:italic>\n \u00a0=\u00a0.004) but not to DFS.\n CDC73<\/jats:italic>\n mutation was not statistically related to DFS or OS.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Negative parafibromin staining indicated a higher risk of recurrence\/metastasis and mortality. The immunohistochemical staining of parafibromin seems to be more promising in predicting outcomes for patients with PC than the sequencing of\n CDC73<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cen.14161","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T13:37:19Z","timestamp":1579181839000},"page":"295-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prognostic role of parafibromin staining and\n CDC73<\/i>\n mutation in patients with parathyroid carcinoma: A systematic review and meta\u2010analysis based on individual patient data"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8500-3267","authenticated-orcid":false,"given":"Ruizhe","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9617-2493","authenticated-orcid":false,"given":"Zixing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics Institute of Basic Medicine Sciences Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-9947","authenticated-orcid":false,"given":"Ya","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1306103"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22599"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491039"},{"key":"e_1_2_9_5_1","first-page":"80","article-title":"Parathyroid carcinoma: diagnosis and clinical implications","volume":"31","author":"Duan K","year":"2015","journal-title":"Turk Patoloji Dergisi"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1571"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-010-0042-6"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200404000-00007"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/324964"},{"key":"e_1_2_9_10_1","first-page":"124","volume-title":"Parathyroid Carcinoma. 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