{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:55:29Z","timestamp":1775148929814,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>The oversecretion of plasma aldosterone by unilateral aldosterone\u2010producing adenoma (APA) can be cured by adrenalectomy. However, the time needed for the endocrine environment to normalize remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify adequate timing for a biochemical evaluation in unilateral APA patients after adrenalectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and patients<\/jats:title><jats:p>A total of 166 unilateral APA patients were retrospectively reviewed. We evaluated the plasma aldosterone concentration (PAC) (pg\/mL), active renin concentration (ARC) (pg\/mL), aldosterone\u2010renin ratio (ARR; PAC\/ARC), serum potassium concentration and estimated glomerular filtration rate (eGFR) at 1, 3 and 6 postoperation months (POM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PAC was significantly lower at 1POM than at presurgery (presurgery; 407.2, 1 POM; 90.0\u00a0pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). ARC did not increase from baseline at 1POM, but significantly increased at 3POM (presurgery; 4.43, 1POM; 4.87, 3POM; 11.3\u00a0pg\/mL, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). ARR significantly decreased at 1POM (presurgery; 146.9, 1 POM; 26.3, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) although ARC did not increase at 1POM. Among the 34 patients who had hypokalaemia presurgery, it was resolved in 28 (82%) at 1POM and in all (100%) at 3POM. The biochemical outcomes at 1POM were 131 (79%) complete, 20 (12%) partial and 15 (9%) absent successes, while at 3POM, 147 (89%) were complete, 9 (5%) partial and 10 (6%) absent. Twenty\u2010three (14%) patients were reclassified into different biochemical outcomes between 1 and 3POM, whereas only 5 (3%) changed between 3 and 6POM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The appropriate timing for a biochemical evaluation of unilateral APA patients treated with laparoscopic adrenalectomy appears to be 3\u00a0months or more after surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14176","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T14:36:09Z","timestamp":1582036569000},"page":"503-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Appropriate timing for a biochemical evaluation after adrenalectomy for unilateral aldosterone\u2010producing adenoma"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-6606","authenticated-orcid":false,"given":"Kimiharu","family":"Takamatsu","sequence":"first","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiya","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo 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Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-6676","authenticated-orcid":false,"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Asanuma","sequence":"additional","affiliation":[{"name":"Department of Urology Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism and Nephrology Department of Internal Medicine Keio University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism 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