{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:25Z","timestamp":1747183885452,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>A 24\u2010hour urine nor\/metanephrine (urine NM\u2010MN) measurements are a recommended first step in pheochromocytoma diagnosis. We hypothesized the presence of renal impairment (CKD) significantly confounds the results obtained in a urine NM\u2010MN collection, giving artificially lower measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective review of a comprehensive laboratory database with all urine NM\u2010MN results from Southern Alberta from 2010 to 2018 (n\u00a0=\u00a015\u00a0505). After excluding high probability pheochromocytoma cases, results from patients with three levels of CKD (n\u00a0=\u00a0796) were compared to those without CKD to determine the potential CKD effect.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>All patients having urine NM\u2010MN collection during the time period, irrespective of ordering physician or test indication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Urine NM\u2010MN was measured by liquid chromatography\u2010tandem mass spectrometry and glomerular filtration rate determined within a median of 1.9\u00a0days, as estimated by CKD\u2010EPI equation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In subjects with mild\u2010to\u2010moderate renal impairment, there was no continuous gradient between subnormal renal function and urine NM\u2010MN measures. When the estimated GFR was\u00a0&lt;\u00a015\u00a0mL\/min\/m<jats:sup>2<\/jats:sup>, the hypothesized effect on lowered urine NM\u2010MN became apparent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A 24\u2010hour urine NM\u2010MN measurement is unlikely to be affected by mild\u2010to\u2010moderate renal impairment and may be used as a reliable diagnostic test. With more advanced renal impairment, CKD\u2010specific reference ranges or an alternative test may be needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14180","type":"journal-article","created":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T07:20:14Z","timestamp":1583392814000},"page":"518-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Moderate renal impairment does not preclude the accuracy of 24\u2010hour urine normetanephrine measurements for suspected pheochromoctyoma"],"prefix":"10.1111","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-9360","authenticated-orcid":false,"given":"Gregory A.","family":"Kline","sequence":"first","affiliation":[{"name":"Department of Medicine\/Endocrinology Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Boyd","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Lab Medicine Cumming School of Medicine University of Calgary Calgary AB Canada"},{"name":"Alberta Public Laboratories Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex A.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Endocrinology Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Endocrinology Cumming School of Medicine University of Calgary Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein M.","family":"Sadrzadeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology and Lab Medicine Cumming School of Medicine University of Calgary Calgary AB Canada"},{"name":"Alberta Public Laboratories Calgary AB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2009.09.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020152"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01532"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00418-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2018.291369"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563216646395"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.121"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(00)00181-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000168820"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.018"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.024703"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2020.01.005"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)62118-6"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(12)80890-0"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.1011"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12394"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/000456329903600504"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1984.00350130075016"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13251.OR"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.67123.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2018.06.018"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0176"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2012.012066"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-3829"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14180","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T07:48:20Z","timestamp":1694072900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,18]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/cen.14180"],"URL":"https:\/\/doi.org\/10.1111\/cen.14180","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2020,3,18]]},"assertion":[{"value":"2020-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}