{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:55:01Z","timestamp":1792727701409,"version":"4.5.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) of the National Institutes of Health (NIH) USA","award":["K23DK121888"],"award-info":[{"award-number":["K23DK121888"]}]},{"name":"Catalyst Award for Advancing in Academics from Mayo Clinic"},{"name":"James A. Ruppe Career Development Award in Endocrinology"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to describe clinical course of myelolipoma and to identify predictors of tumour growth and need for surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Consecutive patients with myelolipoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 321 myelolipomas (median size, 2.3\u00a0cm) were diagnosed in 305 patients at median age of 63\u00a0years (range, 25\u201087). Median follow\u2010up was 54\u00a0months. Most myelolipomas were incidentally detected (86%), whereas 9% were discovered during cancer staging and 5% during workup of mass effect symptoms. Thirty\u2010seven (12%) patients underwent adrenalectomy. Compared to myelolipomas &lt;6\u00a0cm, tumours \u22656\u00a0cm were more likely to be bilateral (21% vs 3%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), cause mass effect symptoms (32% vs 0%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001), have haemorrhagic changes (14% vs 1%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and undergo adrenalectomy (52% vs 5%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Among patients with \u22656\u00a0months of imaging follow\u2010up, median size change was 0\u00a0mm (\u221210, 115) and median growth rate was 0\u00a0mm\/y (\u22126, 14). Compared to &lt;1\u00a0cm growth, \u22651\u00a0cm growth correlated with larger initial size (3.6 vs 2.3\u00a0cm, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), haemorrhagic changes (12% vs 2%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.007) and adrenalectomy (35% vs 8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Most myelolipomas are incidentally discovered on cross\u2010sectional imaging. Myelolipomas \u22656 are more likely to cause mass effect symptoms, have haemorrhagic changes and undergo resection. Tumour growth \u22651\u00a0cm is associated with larger myelolipoma and haemorrhagic changes. Adrenalectomy should be considered in symptomatic patients with large tumours and when there is evidence of haemorrhage or tumour growth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14188","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T18:43:41Z","timestamp":1586544221000},"page":"11-18","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Clinical course of adrenal myelolipoma: A long\u2010term longitudinal follow\u2010up study"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7367-3885","authenticated-orcid":false,"given":"Oksana","family":"Hamidi","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism UT Southwestern Medical Center Dallas TX USA"},{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic Rochester MN 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L.","family":"Lyden","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey B.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benzon M.","family":"Dy","sequence":"additional","affiliation":[{"name":"Department of Surgery Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"William F.","family":"Young","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Bancos","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic Rochester MN 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