{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T22:27:03Z","timestamp":1766788023152,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T00:00:00Z","timestamp":1588636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the specificity of increased <jats:sup>18<\/jats:sup>F\u2010dihydroxyphenylalanine (<jats:sup>18<\/jats:sup>F\u2010FDOPA) uptake in patients who underwent PET\/CT for suspicion of isolated pancreatic neuroendocrine tumour (pNET). False\u2010positive results mimicking a pNET have been investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Carbidopa\u2010assisted <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT scans performed in patients with suspicion of localized pNET were retrieved. Only patients with a definitive diagnosis were retrospectively included. When available, the histopathological result after pancreatic surgery was the gold standard. In other cases, the diagnosis was based on endoscopic ultrasonography (EUS)\/cytology and\/or on concordant imaging results of at least two of the following: contrast\u2010enhanced computed tomography (CE\u2010CT), magnetic resonance imaging (MRI) and somatostatin receptor scintigraphy (SRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four among 731 patients were selected. Among these, 36 patients (82%) were surgically treated, revealing pNET (n\u00a0=\u00a028), solid pseudopapillary tumour (SPT) (n\u00a0=\u00a04), adenocarcinoma (n\u00a0=\u00a02), serous cystadenomas (n\u00a0=\u00a01) and solitary fibrous tumour (n\u00a0=\u00a01) cases. An additional three cases of pNET were diagnosed by EUS\/cytology. In the remaining five patients, a consensus was reached on follow\u2010up imaging results: pNET (n\u00a0=\u00a01), serous cystadenoma (n\u00a0=\u00a02) and undetermined\/no pNET (n\u00a0=\u00a02). Both specificity and negative predictive value of <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT for localized pNET were 67%. Surprisingly, all four false\u2010positive results were SPTs showing intense <jats:sup>18<\/jats:sup>F\u2010FDOPA uptake and negative SRS. There was no significant difference in <jats:sup>18<\/jats:sup>F\u2010FDOPA uptake intensity between PET\u2010positive pNETs and SPTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT is not specific for pNET in patients with localized pancreatic lesions. SPT could mimic pNET and should be part of differential diagnosis in such a clinical situation. If these results are confirmed in a broader population, the imaging pattern <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\u2010positive\/SRS\u2010negative lesions might be considered as the imaging phenotype of SPT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14202","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T03:54:15Z","timestamp":1587441255000},"page":"78-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Solid pseudopapillary tumour should be part of differential diagnosis of focal pancreatic lesions with increased <sup>18<\/sup>F\u2010FDOPA uptake"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1158-7076","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Somme","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging ICANS \u2010 University Hospitals of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Soline","family":"Montaz\u2010Rosset","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging ICANS \u2010 University Hospitals of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerlinde","family":"Averous","sequence":"additional","affiliation":[{"name":"Department of Pathology University Hospital of Strasbourg Strasbourg University Strasbourg France"},{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Deur","sequence":"additional","affiliation":[{"name":"Radiology University Hospitals of Strasbourg Strasbourg University Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"Goichot","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"},{"name":"Internal Medicine, Diabetes and Metabolic Disorders University Hospitals of Strasbourg Strasbourg University Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Bachellier","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"},{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver transplantation University Hospitals of Strasbourg Strasbourg University Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Addeo","sequence":"additional","affiliation":[{"name":"Hepato\u2010Pancreato\u2010Biliary Surgery and Liver transplantation University Hospitals of Strasbourg Strasbourg University Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Imperiale","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging ICANS \u2010 University Hospitals of Strasbourg Strasbourg France"},{"name":"Faculty of Medicine University of Strasbourg Strasbourg France"},{"name":"Molecular Imaging \u2013 DRHIM IPHC UMR 7178 CNRS\/Unistra Strasbourg France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,5]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.179234"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0321"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000061"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200010000-00005"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2015.00024"}],"container-title":["Clinical 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