{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:28Z","timestamp":1747183888471,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T00:00:00Z","timestamp":1589155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1D1A1B03027820","2018R1C1B6004439"],"award-info":[{"award-number":["2017R1D1A1B03027820","2018R1C1B6004439"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Type 2 deiodinase (DIO2)\u2010mediated thyroid hormone synthesis stimulates osteoblast activity and increases the expression of osteoblast differentiation markers, but there are no large cohort studies to identify the role of the DIO2 polymorphism in bone mineral density in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate the hypothesis that individuals with the<jats:italic>DIO2<\/jats:italic>gene polymorphism are susceptible to osteoporosis, we assessed the polymorphism of the<jats:italic>DIO2<\/jats:italic>gene in 7,524 Koreans drawn from the large\u2010scale Ansan\u2010Anseong cohort of the Korean Genome and Epidemiology Study. All of the participants underwent genotyping of the<jats:italic>DIO2<\/jats:italic>Thr92Ala polymorphism (rs225014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 6,022 participants were recruited; 1991 (33.0%) were homozygous for the Thr allele, 2,967 (49.3%) were heterozygous (Thr\/Ala), and 1064 (17.7%) were homozygous for the Ala allele. The effects of the<jats:italic>DIO2<\/jats:italic>Thr92Ala polymorphism on axial speed of sound (SOS) and the T\u2010score in the tibia and radius were assessed, with age, gender, oestrogen status, body mass index (BMI), serum calcium, 25\u2010hydroxyvitamin D, and parathyroid hormone (PTH) included as covariables. Female subjects carrying the<jats:italic>DIO2<\/jats:italic>Thr92Ala polymorphism had significantly lower SOS and T\u2010scores than control participants. Cox regression analysis revealed a significant relationship between the<jats:italic>DIO2<\/jats:italic>polymorphism and diagnosis of osteoporosis in female participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>DIO2<\/jats:italic>Thr92Ala polymorphism is associated with decreased SOS and T\u2010scores in the tibia of female subjects independent of other clinical parameters, where this indicates a potential functional role of DIO2 in the maintenance of bone mineral density.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14206","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T13:40:26Z","timestamp":1587649226000},"page":"238-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Type 2 deiodinase Thr92Ala polymorphism is associated with a reduction in bone mineral density: A community\u2010based korean genome and epidemiology study"],"prefix":"10.1111","volume":"93","author":[{"given":"Yea Eun","family":"Kang","sequence":"first","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Kang","sequence":"additional","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medicine College of Medicine Hanyang University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minho","family":"Shong","sequence":"additional","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases Chungnam National University School of Medicine Daejeon Korea"},{"name":"Department of Medical Science Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3767-1954","authenticated-orcid":false,"given":"Hyon\u2010Seung","family":"Yi","sequence":"additional","affiliation":[{"name":"Research Center for Endocrine and Metabolic Diseases Chungnam National University School of Medicine Daejeon Korea"},{"name":"Department of Medical Science Chungnam National University School of Medicine Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-2760(03)00144-9"},{"issue":"2","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1365-2265.2007.03016.x","article-title":"Effects of serum TSH and FT4 levels and the TSHR\u2010Asp727Glu polymorphism on bone: the Rotterdam Study","volume":"68","author":"Deure WM","year":"2008","journal-title":"Clin Endocrinol"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803103181003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.5161"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/638727"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.049"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2005-0224"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6397"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00664.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.3.E496"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900356"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108497"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.1.8275930"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911346107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-1009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.27"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.090722"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1977"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.880"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29812"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1272"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00325-3"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.155"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0419"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.019190"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI123176"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01196"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000256295.72185.fd"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn082"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2015.180"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.03.660"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(95)00244-8"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2003.09.001"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi105"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050275"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14206","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T15:41:07Z","timestamp":1722786067000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,11]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/cen.14206"],"URL":"https:\/\/doi.org\/10.1111\/cen.14206","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2020,5,11]]},"assertion":[{"value":"2019-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}