{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T20:18:26Z","timestamp":1778098706274,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Failure of cannulation of the right adrenal vein is frequent during AVS for investigation of primary aldosteronism (PA). The aldosterone:cortisol ratio of either adrenal vein compared with the inferior vena cava (AV\/IVC index) has been proposed to differentiate between unilateral and bilateral disease, and aid in lateralization of unilateral disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010two patients with unilateral or bilateral PA identified by either successful bilateral (45 patients) or unilateral (17 patients) adrenal vein cannulation, and with biochemical remission following surgery were enrolled into the analysis. The diagnostic performances of the previously identified AV\/IVC index cut\u2010offs of \u22655.5 to predict ipsilateral disease and \u22640.5 to predict contralateral disease were validated using data from the entire cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three patients had unilateral PA and 9 patients bilateral PA. The area under ROC curve (AUROC) of the AV\/IVC cut\u2010off \u22640.5 for identifying unilateral aldosterone secretion from the contralateral adrenal was 0.95 (95% CI; 0.88\u20100.99), whereas the AUROC of the AV\/IVC cut\u2010off \u22655.5 for identifying unilateral aldosterone secretion from ipsilateral adrenal was 0.96 (95% CI; 0.92\u20100.99). The AV\/IVC index cut\u2010off value of 0.5 had 93% sensitivity and 91% specificity, and the AV\/IVC index cut\u2010off value of 5.5 had 21% sensitivity and 100% specificity. The optimal AV\/IVC cut\u2010offs to achieve 100% specificity for our cohort were &gt;2.4 and &lt;0.1 to predict ipsilateral and contralateral disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data confirm that the AV\/IVC index is a potential tool for subtype classification and lateralization in patients with PA in the setting of failed bilateral, but successful unilateral, adrenal vein cannulation during AVS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14210","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T15:39:46Z","timestamp":1588174786000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Performance of the unilateral AV\/IVC index in primary hyperaldosteronism subtype prediction: A validation study in a single tertiary centre"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7126-866X","authenticated-orcid":false,"given":"Onnicha","family":"Suntornlohanakul","sequence":"first","affiliation":[{"name":"Endocrinology and Metabolism Unit Division of Internal Medicine Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Supamai","family":"Soonthornpun","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Unit Division of Internal Medicine Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wisarut","family":"Srisintorn","sequence":"additional","affiliation":[{"name":"Department of Family and Preventive Medicine Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6730-6109","authenticated-orcid":false,"given":"Robert D.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-4450","authenticated-orcid":false,"given":"Noppadol","family":"Kietsiriroje","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Unit Division of Internal Medicine Faculty of Medicine Prince of Songkla University Hat Yai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2017-00054"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14142"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60834-X"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.01.052"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70298-2"},{"issue":"2","key":"e_1_2_9_7_1","first-page":"331","article-title":"Cardiovascular complications associated with primary aldosteronism: a controlled cross\u2010sectional study","volume":"62","author":"Savard S","year":"2013","journal-title":"Hypertens Dallas Tex 1979"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.01.015"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S13783"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-4061"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2013.610"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40137-013-0038-6"},{"key":"e_1_2_9_13_1","first-page":"17","article-title":"Adrenal vein sampling in the diagnosis of aldosteronism","volume":"3","author":"Rahmi Oklu R","year":"2015","journal-title":"J Vasc Diagn"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1342"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjr.2019.84178"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06305"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2015.06.048"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2017.10.012"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.005574"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3676"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12669"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-4327-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0104"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01774"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14210","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T05:37:29Z","timestamp":1693892249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/cen.14210"],"URL":"https:\/\/doi.org\/10.1111\/cen.14210","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"assertion":[{"value":"2020-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}