{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T23:02:07Z","timestamp":1781478127507,"version":"3.54.1"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This analysis of previously published reports was performed to examine the effects of gonadotropin\u2010releasing hormone (GnRH) agonist treatment on adult height and the factors associated with adult height outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>GnRH agonists are first\u2010line agents in the treatment of precocious puberty. However, studies regarding the treatment effect on subjects with early puberty have reported inconsistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A total of 14 studies identified from a search of electronic databases (AMED, EMBASE, MEDLINE and RISS) were included. Controlled studies with girls who developed puberty before 10\u00a0years of age and measurements of the adult heights of the subjects were selected. Studies using only long\u2010acting GnRH agonists to suppress puberty were included. Adult height, duration of the treatment, age at the start of treatment and bone age advancement were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the subjects ranged from 6.3 to 9.0\u00a0years. The meta\u2010analysis showed a pooled mean difference in adult height of 3.2\u00a0cm and a 95% confidence interval of 1.3\u20105.1\u00a0cm. The height difference between the treated subjects and controls was significantly associated with the duration of treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005) rather than the age at the start of treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.084) or the difference between bone age and chronological age (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.427).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of GnRH agonists in girls who develop early puberty and demonstrate advanced bone age may be effective for increasing adult height, especially if a sufficiently long treatment duration can be achieved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14214","type":"journal-article","created":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T21:19:28Z","timestamp":1589231968000},"page":"135-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adult height after gonadotropin\u2010releasing hormone agonist treatment in girls with early puberty: A meta\u2010analysis"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-1088","authenticated-orcid":false,"given":"Hong Kyu","family":"Park","sequence":"first","affiliation":[{"name":"Department of Pediatrics Gyeongsang National University Changwon Hospital  Changwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7852-5822","authenticated-orcid":false,"given":"Min Soo","family":"Choo","sequence":"additional","affiliation":[{"name":"Department of Urology Seoul National University College of Medicine, Seoul Metropolitan Government Boramae Medical Center  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-5279","authenticated-orcid":false,"given":"Young Suk","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hallym University Dongtan Sacred Heart Hospital  Hwaseong Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200102000-00019"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.347"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.815"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2188"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010077"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.e72"},{"key":"e_1_2_7_8_1","first-page":"443","article-title":"Socioeconomic status, race, and girls\u2019 pubertal maturation: Results from the project on human development in Chicago neighborhoods","volume":"10","author":"Obeidallah DA","year":"2000","journal-title":"J Adolesc Health"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60366-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.4.323"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0814"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70221-0"},{"key":"e_1_2_7_14_1","first-page":"16","article-title":"Variations in duration of pubertal growth: a mechanism compensating for differences in timing of puberty and minimizing their effects on final height. 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