{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T06:22:08Z","timestamp":1787984528626,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T00:00:00Z","timestamp":1592784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Comprehensive data about patients with bilateral pheochromocytoma are limited. We aimed to describe the clinical presentation, genetic analysis, treatment and outcomes of patients with bilateral pheochromocytoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective study at a tertiary care centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>All patients with bilateral pheochromocytoma evaluated at Mayo Clinic in Rochester, Minnesota between January 1951 and December 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Tumour size, genetic testing, plasma\/urine metanephrines and catecholamines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 94 patients (51% women) were diagnosed with bilateral pheochromocytoma at a median age at first presentation of 31\u00a0years (range, 4\u201070). Bilateral disease was noted in 8.0% of pheochromocytoma patient overall and 37.5% of patients 18\u00a0years of younger. Most patients presented with synchronous tumours (80%). Median time to metachronous tumours was 4.5\u00a0years (range, 1\u201038). Genetic disease was identified in 75 (80%) patients, including MEN 2A (42.6%), VHL (19.1%), MEN 2B (9.6%) and NF1 (8.5%). Excess catecholamines were present in 97% of patients. Patients with synchronous pheochromocytoma commonly underwent simultaneous bilateral adrenalectomy (99%), and 18 (24%) had cortical\u2010sparing surgery. Multicentric tumours were reported in 23 of 77 (30%) patients with available data. Recurrent disease was found in 9.6% of patients, and 8.5% developed metastatic disease. Median follow\u2010up was 8.5\u00a0years. At the study conclusion, 4 patients had died due to pheochromocytoma or adrenalectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bilateral pheochromocytoma occurred in 7.0% of adults with pheochromocytoma and 37.5% of paediatric patients. Genetic disease was identified in 80% of patients, predominantly MEN2A. Multicentric tumours were common, but most were still cured following adrenalectomy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14222","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T03:34:42Z","timestamp":1589513682000},"page":"288-295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bilateral pheochromocytoma: Clinical characteristics, treatment and longitudinal follow\u2010up"],"prefix":"10.1111","volume":"93","author":[{"given":"Nana Esi","family":"Kittah","sequence":"first","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Nutrition Mayo Clinic Rochester MN USA"},{"name":"Health Care Partners of Nevada, Endocrinology Las Vegas NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4329-3352","authenticated-orcid":false,"given":"Lucinda 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