{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:17:20Z","timestamp":1786969040147,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the study was to compare the long\u2010term outcomes of patients with localized adrenocortical carcinoma (ACC) subjected to open vs laparoscopic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>This retrospective study included 46 patients with the ACC ENSAT stage I\u2010stage III of whom 23 underwent open surgery (OA group), whereas 23 were subjected to laparoscopic adrenalectomy (LA group). The main outcomes analysed in the study were differences between the OA and LA groups in recurrence\u2010free survival (RFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients in OA group had larger tumours (120 [70\u2010250] mm vs 75 [26\u2010110] mm; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), higher Ki\u201067 index (16 [1\u201065] % vs 10 [1\u201025] %; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) and higher disease stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01) compared with the patients in the LA group. The median duration of follow\u2010up for patients underwent OA and LA was 51 (12\u2010174) and 53 (5\u2010127) months, respectively. Eight patients (5 OA and 3 LA) experienced recurrent disease, whereas six patients (3 OA and 3 LA) died during follow\u2010up. No differences in RFS and OS were found between patients who underwent open or laparoscopic surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated that in patients with localized ACC and without invasion of extra\u2010adrenal tissues, LA is a plausible treatment option in terms of RFS and OS. However, our results are limited to referral centres with large experience in the management of patients with ACC and may not necessarily apply to nonspecialized centres.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14251","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T21:33:30Z","timestamp":1589837610000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Open vs laparoscopic adrenalectomy for localized adrenocortical carcinoma"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3034-5598","authenticated-orcid":false,"given":"Darko","family":"Kastelan","sequence":"first","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola","family":"Knezevic","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"},{"name":"Department of Urology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Zibar Tomsic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u2010Marija","family":"Alduk","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"},{"name":"Department of Radiology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Kakarigi","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Kastelan","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana","family":"Coric","sequence":"additional","affiliation":[{"name":"School of Medicine University of Zagreb Zagreb Croatia"},{"name":"Department of Pathology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Skoric\u2010Polovina","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirsala","family":"Solak","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Kraljevic","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Balasko","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Gnjidic","sequence":"additional","affiliation":[{"name":"Department of Oncology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Dusek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology University Hospital Centre Zagreb Zagreb Croatia"},{"name":"School of Medicine University of Zagreb Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3020"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2011.0376"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-1096"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0532-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0608"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.06.024"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.01.036"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3164-6"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.765065"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2017.0546"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198903000-00004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/106689690401200304"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.08.010"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2012.08.014"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-01918-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3034-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.07.026"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0716-x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0923"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-13-0242"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:40:26Z","timestamp":1693950026000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,21]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cen.14251"],"URL":"https:\/\/doi.org\/10.1111\/cen.14251","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,21]]},"assertion":[{"value":"2020-03-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}