{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:27:22Z","timestamp":1768354042663,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Multiple endocrine neoplasia type 1 (MEN 1) is characterized by multisystem neoplasia including primary hyperparathyroidism and pituitary adenoma. Despite the adolescent onset of endocrinopathies, information regarding the impact of maternal MEN 1 on pregnancy is limited to case reports.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore pregnancy outcomes in MEN 1 positive women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case series of maternofoetal outcomes MEN 1 positive mothers managed at the Royal Hobart Hospital between 1967 and 2018. Data were retrieved from medical records and Australian averages calculated based on the Australian Institute of Health and Welfare data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six women with MEN 1 were identified accounting for 96 pregnancies and 76 live born infants. Hyperparathyroidism was evident in 16 pregnancies. A significant increase in serum calcium in the second trimester (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u00a00.14, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001) occurred that was not mediated by parathyroid hormone. Hypercalcaemia was mild\u2010moderate with parathyroidectomy or medical management required in one and four pregnancies, respectively. Compared to the Australian average, women with MEN 1 were more likely to develop gestational diabetes (56% vs 8.9%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001), hypertensive disorders (25.9% vs 7.6, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018), have shorter gestations (38.1 vs 38.7\u00a0weeks, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.015) and have low birthweight infants (30.1% vs 6.5%, <jats:italic>P\u00a0=\u00a0<\/jats:italic>.001). However, emergency caesarean deliveries (63.2% vs 52.3%) and miscarriage rate (20.8% vs 20%) were not significantly different.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal MEN 1 is associated with an increased risk of gestational diabetes, hypertensive disorders and low neonatal birthweight, but not with an increased miscarriage rate. Whilst hypercalcaemia worsens during the second trimester, most pregnancies progressed without overt complications or requirement for intervention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14252","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:31:54Z","timestamp":1589779914000},"page":"429-438","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The clinical expression and impact of multiple endocrine neoplasia 1 during pregnancy"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6225-9240","authenticated-orcid":false,"given":"Prudence","family":"Hogg","sequence":"first","affiliation":[{"name":"Department of General Medicine Royal Hobart Hospital Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1425-5808","authenticated-orcid":false,"given":"Michael","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Royal Hobart Hospital Hobart Tasmania Australia"},{"name":"School of Medicine University of Tasmania Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Burgess","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Endocrinology Royal Hobart Hospital Hobart Tasmania Australia"},{"name":"School of Medicine University of Tasmania Hobart Tasmania Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-129-6-199809150-00011"},{"key":"e_1_2_10_3_1","volume-title":"Multiple Endocrine Neoplasia Type 1","author":"Giusti F","year":"2005"},{"key":"e_1_2_10_4_1","first-page":"484","article-title":"Clinical expression of MEN1 at NIH","volume":"129","author":"Skarulis M","year":"1998","journal-title":"Ann Int Med"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"217","article-title":"Management of a multiple endocrine neoplasia type 1 during pregnancy: a case report and review of the literature","volume":"11","author":"Daglar H","year":"2016","journal-title":"J Exp Ther Oncol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X14532634"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03495.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2017.08.110"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-208829"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6061313"},{"issue":"4","key":"e_1_2_10_11_1","first-page":"341","article-title":"Pregnancy complicated by concurrent primary hyperparathyroidism and arrhythmia","volume":"99","author":"Lin C","year":"2000","journal-title":"J Formos Med Assoc"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3297-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00302-X"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-002-0316-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-200206000-00022"},{"key":"e_1_2_10_16_1","unstructured":"Australian Government Department of Health.Prescribing medicines in pregnancy database[Internet] 2019[cited 20\/10\/2019]. Available from:https:\/\/www.tga.gov.au\/prescribing\u2010medicines\u2010pregnancy\u2010database. October 20 2019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-01104"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.6.832"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00027.2015"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb133152.x"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410320017001"},{"key":"e_1_2_10_22_1","unstructured":"National Institute for Health and Care Excellence.Preterm Labour and Birth National Institute for Health and Care Excellence;2015. Contract No.: NICE Guidelines No. 25."},{"key":"e_1_2_10_23_1","volume-title":"International statistical classification of diseases and related health problems, tenth revision","author":"World Health Organisation","year":"2004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12399"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2345"},{"key":"e_1_2_10_27_1","unstructured":"Welfare AIoHa.Diabetes in pregnancy: its impact on Australian women and their babies.Canberra ACT:AIHW;2010."},{"key":"e_1_2_10_28_1","unstructured":"Australian Institute of Health and Welfare.Australia's mothers and babies 2016\u2014in brief.Canberra ACT:AIHW;2018."},{"key":"e_1_2_10_29_1","unstructured":"Welfare AIoHa.Improving national reporting on diabetes in pregnancy: technical report.Canberra ACT:AIHW;2019."},{"key":"e_1_2_10_30_1","unstructured":"CoOaPMa.Morbidity Annual Report 2016. In: Health Do editor. Tasmania;2016."},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.05.006"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/67.4.693"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3659"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14067"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02563.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2005.09.008"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04166.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1146812"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-16-0090"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz231"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000254119.99660.e7"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0012"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00275.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/301953"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14252","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14252","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14252","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T21:40:31Z","timestamp":1693950031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cen.14252"],"URL":"https:\/\/doi.org\/10.1111\/cen.14252","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"assertion":[{"value":"2020-03-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}