{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:34Z","timestamp":1747183894472,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["SNF\u2010162608"],"award-info":[{"award-number":["SNF\u2010162608"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011033","name":"Thermo Fisher Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Arginine vasopressin (AVP) is released upon osmotic stimulation or hypovolaemia in order to maintain water balance. A recent study showed a role of AVP in haematopoiesis by stimulating red blood cell precursors, suggesting a higher risk of anaemia in patients with AVP deficiency.<\/jats:p><jats:p>The objective was to explore the effect of low AVP levels in patients with central diabetes insipidus (cDI) and primary polydipsia (PP) on haemoglobin and the prevalence of anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 164 patients with either cDI (70, 43%) or PP (94, 57%) and 30 healthy volunteers from two prospective diagnostic studies performed in Switzerland, Germany and Brazil were studied. A standardized clinical and biochemical (eg copeptin, full blood count) assessment was performed. Haemoglobin and haematocrit levels and prevalence of anaemia (defined as haemoglobin values of &lt;120\u00a0g\/L in women and &lt;130\u00a0g\/L in men) were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean copeptin values were 2.63\u00a0pmol\/L (\u00b11.08) and 3.91\u00a0pmol\/L (\u00b14.28) in patients with cDI and PP and 24.76\u00a0pmol\/L (\u00b15.75) in healthy volunteers, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02. The prevalence of anaemia was low in all participants with 7.1%, 2.2% and 10% in cDI, PP and in healthy volunteers, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.15. Mean haemoglobin values were similar in all groups: 139\u00a0g\/L (\u00b115.85), 140\u00a0g\/L (\u00b113.16) and 139\u00a0g\/L (\u00b113.05) in patients with cDI, PP and healthy volunteers, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.90, as were mean haematocrit values with 41% in all groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic low AVP levels in patients with cDI and PP do not affect haemoglobin levels and prevalence of anaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14265","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T21:43:40Z","timestamp":1592084620000},"page":"456-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Low arginine vasopressin levels in patients with diabetes insipidus are not associated with 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