{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:09:41Z","timestamp":1787062181757,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Age at first date and sexual intercourse have been observed to be delayed in women with Turner syndrome (TS), with delayed puberty being the main factor. We sought to assess relationship and sexual experiences comparing women with TS and premature ovarian insufficiency (POI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients<\/jats:title>\n                    <jats:p>302 women with TS and 53 women with karyotypically normal POI (median age 33.0 [15.0\u201078.4] and 26.3 [17.8\u201052.3], respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>A self\u2010reporting questionnaire was used to collect data on relationship and sexual experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with TS were older than women with POI (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002). Compared to women with POI, a smaller proportion of women with TS had ever had vaginal sexual intercourse (VSI) (40 [78.4%] vs 169 [58.1%], respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.006) and women with TS exhibited a delay in the median age at first relationship and VSI (POI 19.3\u00a0\u00b1\u00a00.4 vs TS 22.2\u00a0\u00b1\u00a01.1,\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0&lt;.001). Start of oestrogen replacement therapy at\u00a0\u2264\u00a014\u00a0years of age compared with\u00a0&gt;\u00a014\u00a0years did not result in earlier relationship and sexual debut. After adjusting for age and diagnosis, induction of puberty, as opposed to spontaneous puberty, was associated with a delay in the median age at first relationship and VSI and a reduced probability of having VSI (Hazard ratio\u00a0=\u00a00.44 [95% confidence interval: 0.32\u20100.60],\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a0&lt;.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Turner syndrome and induction of puberty are associated with a reduced likelihood and a delay in relationship and sexual experiences. Women needing puberty induction and women with TS more than POI have a delayed mean age at first VSI compared to the general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.14271","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T15:54:05Z","timestamp":1593014045000},"page":"473-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Relationship and sexual experiences in women with early\u2010onset oestrogen deficiency: Comparison between women with Turner syndrome and premature ovarian insufficiency"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0947-8153","authenticated-orcid":false,"given":"Carol","family":"Cardona Attard","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoinette","family":"Cameron\u2010Pimblett","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davina","family":"Puri","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"La Rosa","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram S.","family":"Talaulikar","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie C.","family":"Davies","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazel I.","family":"Learner","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lih\u2010Mei","family":"Liao","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard S.","family":"Conway","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit University College London Hospitals London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14681990601149197"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00926230701636163"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03715.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2007.0488"},{"issue":"484","key":"e_1_2_8_6_1","first-page":"e481","article-title":"Turner's syndrome and other forms of congenital hypogonadism impair quality of life and sexual function","volume":"208","author":"Ros C","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2652"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.12.1374"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1615289"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2017.07.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62071-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62035-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2008.04.005"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1995.tb03929.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01674820701577078"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1542\/peds.102.S3.488","article-title":"The psychological consequences of Turner syndrome and review of the National Cooperative Growth Study psychological substudy","volume":"102","author":"Siegel PT","year":"1998","journal-title":"Pediatrics"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200112000-00003"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31687"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3177"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(98)71322-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13394"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3181f4318d"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/gme.0b013e3180f6108c"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.08.040"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0514"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431002"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000179049.08371.c7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.7.672"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072947"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.14271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14271","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14271","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T17:40:34Z","timestamp":1693935634000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/cen.14271"],"URL":"https:\/\/doi.org\/10.1111\/cen.14271","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,10]]},"assertion":[{"value":"2020-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}