{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:39:07Z","timestamp":1789817947260,"version":"4.0.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of antenatal corticosteroids (ANS) on the maturation of thyroid function in the preterm infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>ANS reduce mortality and morbidities in preterm neonates. Organ maturation by the glucocorticoids is the key, at least in part. However, the effect of ANS on thyroid is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A study group of 99 very low birthweight neonates (&lt;34\u00a0weeks\u2019 gestational age) with the exception of those born more than 7\u00a0days after ANS administration were divided into a complete group (n\u00a0=\u00a049) whose mothers completed two doses of betamethasone and who were born more than 24\u00a0hours after the completion of ANS administration, and an incomplete group (n\u00a0=\u00a050) who were not exposed to any ANS or were born within 24\u00a0hours after the completion of ANS administration. Serum\u2010free thyroxine and thyroid\u2010stimulating hormone (TSH) levels were measured, and thyrotropin\u2010releasing hormone (TRH) stimulation tests were performed at about 2\u00a0weeks of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of hyperthyrotropinaemia (TSH\u00a0&gt;\u00a015 mIU\/L) in the complete group was significantly lower than in the incomplete group (6% vs 22%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.023). Exaggerated responses to TRH tests were more frequent in the incomplete group (17% vs 44%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.053). TSH<jats:sub>30<\/jats:sub> was significantly lower in the complete group, (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.046). Multivariate logistic regression analysis showed that the incidence of hyperthyrotropinaemia was associated with complete ANS administration (adjusted odds ratios 0.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ANS administration might facilitate thyroid maturation in preterm neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14272","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T09:41:12Z","timestamp":1593250872000},"page":"613-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Antenatal corticosteroids for threatened labour facilitate thyroid maturation among preterm neonates"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4082-3904","authenticated-orcid":false,"given":"Shintaro","family":"Hanaoka","sequence":"first","affiliation":[{"name":"Department of Pediatrics Graduate School of Medicine Kyoto 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