{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:50:08Z","timestamp":1766760608254,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We evaluated sequelae of disease and therapy in adolescents with chronic endocrinopathies using a medical and psychological workup to record health\u2010related quality of life (HRQoL), near final height (NFH) and body compositions during the transition period from paediatric to adult care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Near final height, weight, body mass index (BMI), grip strength (GS), hip and waist circumference (HC; WC), skin folds (SF) and HRQoL T\u2010scores by KIDSCREEN and DISABKIDS were assessed in 134 patients (70 females and 64 males) from May 2010 to March 2016 diagnosed with congenital adrenal hyperplasia (CAH; n\u00a0=\u00a022), multiple pituitary hormone deficiency (MPHD; n\u00a0=\u00a017), growth hormone deficiency (GHD; n\u00a0=\u00a037), Turner syndrome (TS; n\u00a0=\u00a027), SGA\u2010short stature (SGA; n\u00a0=\u00a020) and Klinefelter syndrome (KS; n\u00a0=\u00a011).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median HRQoL T\u2010scores for KIDSCREEN (50.6\u201056.5) and DISABKIDS (52.7\u201058.9) ranged within references with considerable variations but without significant deficit in any diagnosis. Median\u2010corrected height SDS (CoH\u2010SDS: NFH\u2010SDS\u2013TH [target height]\u2010SDS) was &gt;\u22121, except in KS (SDS\u00a0+\u00a01.3) and in TS (SDS \u2013 1.9; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) without correlations with HRQoL. Median BMI was below 25\u00a0kg\/m<jats:sup>2<\/jats:sup> in all patients except MPHD (26.5\u00a0kg\/m<jats:sup>2<\/jats:sup>; SDS 1.5; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006). BMI correlated negatively in CAH females with self\u2010perception (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u2212.64, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0338), physical well\u2010being (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u2212.8; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0086), social exclusion <jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u2212.65; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.031) and emotions (<jats:italic>r<\/jats:italic><jats:sub>s<\/jats:sub>\u00a0=\u00a0\u2212.7; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0169).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Health\u2010related quality of life and body compositions were similar to those of healthy adolescents. Lower scores in HRQoL dimensions as self\u2010perception, physical well\u2010being, social exclusion and emotions were detected and correlated negatively with BMI. Treatment strategies and psychological support should consider HRQoL and adapted in specific treatment guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14287","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T22:08:35Z","timestamp":1595110115000},"page":"696-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relation of health\u2010related quality of life to near final height and body composition in adolescents with chronic endocrinopathies during transition period"],"prefix":"10.1111","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6106-2959","authenticated-orcid":false,"given":"Janna","family":"Mittnacht","sequence":"first","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Choukair","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Breil","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Klose","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes Department of Paediatrics University Hospital Heidelberg Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Inta","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes 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