{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:38Z","timestamp":1747183898663,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein\u2010to\u2010peripheral vein ratio (LAV\/PV) were proposed to predict the lateralization index without the right AVS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess external validity of MRM and LAV\/PV to predict lateralization index when right adrenal vein sampling is missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Diagnostic retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Development and validation cohorts included AVS of 174 and 122 patients, respectively, from 2 different centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Development and validation cohort data were used, respectively, for calibration and for validation of MRM and LAV\/PV to predict the lateralization index without the right adrenal vein sampling. Sensitivity and specificity of MRM and LAV\/PV were compared between both centres at different pre\u2010established specificity thresholds based on receiver operating characteristic curves generated from the development cohort data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a specificity threshold of 95% set in the development cohort, specificity values exceeded 90% (range, 90.6%\u201098.8%) for all verified MRM and LAV\/PV models in the validation cohort. Corresponding sensitivities for MRM and LAV\/PV, respectively, range from 54.1% to 83.7% and 32.8% to 88.4% for the development cohort compared to 33.3%\u201087.5% and 2.8%\u201079.2% for the validation cohort. Overall, diagnostic accuracy of both methods was higher to detect right (82.8%\u201093.5%) than left (70.2%\u201080.6%) lateralization index status in both centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Minimal changes in specificity from development to validation cohorts validate the use of MRM and LAV\/PV to predict the lateralization index when the right AVS is missing. Both methods had better accuracy for right than left lateralization detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14295","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T20:55:10Z","timestamp":1595278510000},"page":"661-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adrenal vein sampling: External validation of multinomial regression modelling and left adrenal vein\u2010to\u2010peripheral vein ratio to predict lateralization index without right adrenal vein sampling"],"prefix":"10.1111","volume":"93","author":[{"given":"Roxanne","family":"Bouchard\u2010Bellavance","sequence":"first","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Perrault","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilles","family":"Soulez","sequence":"additional","affiliation":[{"name":"Department of Radiology Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montreal QC Canada"},{"name":"Centre de Recherche du CHUM (CRCHUM)  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Chagnon","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics Pavillon Andr\u00e9\u2010Aisenstadt University of Montreal  Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8129-9360","authenticated-orcid":false,"given":"Gregory A.","family":"Kline","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Medicine Foothills Medical Center (FMC)  Calgary AB 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