{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:09:36Z","timestamp":1790233776922,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In patients with ileal neuroendocrine tumours (ileal NETs), head\u2010to\u2010head evaluation of diagnostic performances of <jats:sup>68<\/jats:sup>Ga\u2010DOTA\u2010peptides and <jats:sup>18<\/jats:sup>F\u2010fluorodihydroxyphenylalanine (<jats:sup>18<\/jats:sup>F\u2010FDOPA) positron emission tomography\/computed tomography (PET\/CT) has been performed in only few small patients\u2019 cohorts. The aim of this retrospective study was to compare <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC and <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT for metastatic disease assessment in a homogeneous large series of patients with well\u2010differentiated ileal NETs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with ileal NETs who underwent both <jats:sup>18<\/jats:sup>F\u2010FDOPA and <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT within a 3\u2010month period and no therapeutic change between the two studies were retrospectively included. The detection rates of both modalities were calculated using per\u2010patient, per\u2010region and per\u2010lesion analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty one patients with ileal NETs were evaluated. <jats:sup>18<\/jats:sup>F\u2010FDOPA and <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC showed similar detection rates according to per\u2010patient (97% for both) and per\u2010region analyses (94% for <jats:sup>18<\/jats:sup>F\u2010FDOPA vs 88% for <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.35). For a total of 605 positive lesions, 458 (76%) were detected by both modalities, 122 (20%) exclusively by <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT, and 25 (4%) by <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT only. In a per\u2010lesion analysis, <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT performed better than <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT (overall detection rates of 96% vs 80%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). <jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT detected significantly more metastases than <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT in the liver, peritoneum, abdominal and supra\u2010diaphragmatic lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:sup>18<\/jats:sup>F\u2010FDOPA PET\/CT seems not inferior than <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT for the delineation of metastatic spread of ileal NETs. Therefore, according to local expertise and technical availability, <jats:sup>18<\/jats:sup>F\u2010FDOPA should be considered as a valid clinical diagnostic option for exhaustive metastatic assessment in patients with ileal NETs. Obviously, <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET\/CT remains mandatory for PRRT assessment. Further comparative studies are needed to determine the optimal approach in various clinical scenarios such as preoperative staging and primary tumour detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14312","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T21:49:21Z","timestamp":1597355361000},"page":"66-73","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Intraindividual comparison of <sup>18<\/sup>F\u2010FDOPA and <sup>68<\/sup>Ga\u2010DOTATOC PET\/CT <i>detection rate<\/i> for metastatic assessment in patients with ileal neuroendocrine tumours"],"prefix":"10.1111","volume":"94","author":[{"given":"Eric","family":"Ouvrard","sequence":"first","affiliation":[{"name":"Nuclear Medicine and Molecular Imaging ICANS University Hospitals of Strasbourg  Strasbourg 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