{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T15:21:40Z","timestamp":1787325700284,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["PG\/13\/28\/29833"],"award-info":[{"award-number":["PG\/13\/28\/29833"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) is associated with metabolic risk. Complement proteins regulate inflammation and lipid clearance but their role in PCOS\u2010associated metabolic risk is unclear. We sought to establish whether the complement system is activated in PCOS in the fasting and postprandial state.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Fasting complement levels were measured in 84 women with PCOS and 95 healthy controls. Complement activation post\u2010oral fat tolerance test (OFTT) was compared in 40 additional subjects (20 PCOS, 20 controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Activation pathway (C3, C4, C3a(desArg), factor B, factor H, properdin, Factor D) and terminal pathway (C5, C5a, terminal complement complex [TCC]) proteins were measured by commercial or in\u2010house assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fasting C3, C3a(desArg) and TCC concentrations were increased in insulin\u2010resistant (adjusted differences: C3 0.13\u00a0g\/L [95%CI 0\u20100.25]; C3a(desArg) 319.2\u00a0ng\/mL [19.5\u2010619]; TCC 0.66\u00a0\u03bcg\/mL [0.04\u20101.28]) but not in insulin\u2010sensitive women with PCOS. C3 and factor H levels increased with obesity. Post\u2010OFTT, C3 and C4 levels increased to a similar extent in PCOS subjects and controls, whist factor H levels increased more in women with PCOS compared to controls (adjusted differences (area under the curve): 12\u00a0167\u00a0\u03bcg\u00a0min\/mL [4942\u201019\u00a0392]), particularly in the presence of concomitant obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Activation and terminal complement pathway components are elevated in patients with PCOS, especially in the presence of insulin resistance and obesity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14322","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T10:16:01Z","timestamp":1598868961000},"page":"74-84","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Complement activation in polycystic ovary syndrome occurs in the postprandial and fasted state and is influenced by obesity and 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