{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:45:10Z","timestamp":1783647910452,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>[<jats:sup>18<\/jats:sup>F]FDG PET\/CT improves adrenal tumour characterization. However, there is still no consensus regarding the optimal imaging biomarkers of malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the performance of Tumour standardized uptake value (SUV)<jats:sub>max<\/jats:sub>:Liver SUV<jats:sub>max<\/jats:sub> for malignancy\u2010risk and to build and evaluate a prediction model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Methods<\/jats:title><jats:p>The cohort consisted of consecutive patients with adrenal masses evaluated by [<jats:sup>18<\/jats:sup>F]FDG PET\/CT. The gold standard for malignancy was based on histology or a multidisciplinary consensus in nonoperated cases. The performance of the previously reported cut\u2010off for Tumour SUV<jats:sub>max<\/jats:sub>:Liver SUV<jats:sub>max<\/jats:sub> (&gt;1.5) was evaluated in this independent cohort. Additionally, a predictive model of malignancy was built from the training cohort (previous study) and evaluated in the validation cohort (current study).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients were evaluated; 28% of them had a Cushing's syndrome. Fifty\u2010four adrenal masses were classified as benign and 10 as malignant (including 7 adrenocortical carcinomas). Compared to benign masses, malignant lesions were larger in size, had higher unenhanced densities and higher [<jats:sup>18<\/jats:sup>F]FDG uptake. CT\u2010derived anthropometric parameters did not differ between benign and malignant masses. A tumour SUV<jats:sub>max<\/jats:sub>:Liver SUV<jats:sub>max<\/jats:sub>\u00a0&gt;\u00a01.5 showed a good diagnostic performance: Se\u00a0=\u00a090.0%\/Sp\u00a0=\u00a092.6%\/PPV\u00a0=\u00a069.2%\/NPV\u00a0=\u00a098.0% and accuracy\u00a0=\u00a092.2%. A predictive model based on tumour size and tumour\u2010to\u2010liver uptake SUV<jats:sub>max<\/jats:sub> ratio for malignancy\u2010risk was validated and provides a complementary approach to the ratio.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tumour SUV<jats:sub>max<\/jats:sub>:Liver SUV<jats:sub>max<\/jats:sub> uptake ratio is a useful biomarker for diagnosis of adrenal masses. Another tactic would be to calculate with the model an individual risk of malignancy and integrate this information into a shared decision\u2010making process.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14338","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T05:16:30Z","timestamp":1601097390000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk stratification of adrenal masses by [<sup>18<\/sup>F]FDG PET\/CT: Changing tactics"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0889-0226","authenticated-orcid":false,"given":"Betty","family":"Salgues","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire Centre Hospitalo\u2010Universitaire de la Timone APHM Centre Europ\u00e9en de Recherche en Imagerie M\u00e9dicale Aix Marseille Univ Marseille 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