{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:08:40Z","timestamp":1780628920266,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T00:00:00Z","timestamp":1602288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006390","name":"Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Stereotactic radiosurgery (SRS) is a valuable treatment option for persistent and\/or recurrent acromegaly secondary to growth hormone (GH) secreting pituitary adenoma (PA). Here, we assess the role of biological effective dose (BED) received by PA treated with SRS in relation with endocrine remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010two patients (minimum 6\u00a0months follow\u2010up) were included. Mean marginal dose was 27.7 (median 28, 20\u201335), and mean BED received by tumour was 193.1\u00a0Gy<jats:sub>2.47<\/jats:sub> (median 199.7, 64.1\u2013237.1). Based on the median values, we divided the patients in high tumour BED group (H\u2010BEDtm, 199.7\u2013237.1\u00a0Gy<jats:sub>2.47,<\/jats:sub> <jats:italic>n<\/jats:italic>\u00a0=\u00a012) and low BED one (L\u2010 BEDtm, 64.1\u2013199.7\u00a0Gy<jats:sub>2.47<\/jats:sub>, <jats:italic>n<\/jats:italic>\u00a0=\u00a010). The two groups did not differ by pretherapeutic IGF\u20101 levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.1) or by the prescribed dose (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up period was 62.5\u00a0months (median 60.5, 9\u2013127). Probability of IGF\u20101 normalization was 65% at 3\u00a0years and 72.4% at 4\u00a0years, remaining stable until last follow\u2010up. Twenty\u2010two (52.4%) patients had complete endocrine remission in absence of any Somatostatin analogues. Actuarial rates were 33% at 3\u00a0years and 57.4% at 7\u00a0years, further remaining stable during follow\u2010up course. In univariate analysis, only statistically significant parameter was pretherapeutic serum IGF\u20101 and IGF\u20101 index (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Five patients (5\/26, 19.3%) without previous hypopituitarism developed new pituitary insufficiency. H\u2010BEDtm was associated with higher rates of endocrine remission compared with L\u2010BEDtm, with actuarial probability of 70.2% versus 48.2% at 9\u00a0years, although this did not reach statistical significance (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study confirms that SRS by Gamma Knife is safe and effective for GH\u2010secreting PA. Pretherapeutic serum levels of IGF\u20101 were only statistically significant parameter for endocrine remission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14346","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T10:01:28Z","timestamp":1601287288000},"page":"424-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Gamma Knife radiosurgery for acromegaly: Evaluating the role of the biological effective dose associated with endocrine remission in a series of 42 consecutive cases"],"prefix":"10.1111","volume":"94","author":[{"given":"Anne","family":"Balossier","sequence":"first","affiliation":[{"name":"Assistance Publique Hopitaux de Marseille Stereotactic and Functional Neurosurgery Service and Gamma Knife Unit CHU Timone Marseille France"},{"name":"Clinical Neurosurgery Service Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6776-1486","authenticated-orcid":false,"given":"Constantin","family":"Tuleasca","sequence":"additional","affiliation":[{"name":"Clinical Neurosurgery Service Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"},{"name":"Department of Clinical Neurosciences Neurosurgery Service and Gamma Knife Center Lausanne University Hospital (CHUV) Lausanne Switzerland"},{"name":"Faculty of Biology and Medicine (FBM) University of Lausanne (Unil) Lausanne Switzerland"},{"name":"Signal Processing Laboratory (LTS 5) Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne (EPFL) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cortet\u2010Rudelli","sequence":"additional","affiliation":[{"name":"Endocrinology Department Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Soto\u2010Ares","sequence":"additional","affiliation":[{"name":"Neuroradiology Department Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Levivier","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences Neurosurgery Service and Gamma Knife Center Lausanne University Hospital (CHUV) Lausanne Switzerland"},{"name":"Faculty of Biology and Medicine (FBM) University of Lausanne (Unil) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Assaker","sequence":"additional","affiliation":[{"name":"Clinical Neurosurgery Service Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Reyns","sequence":"additional","affiliation":[{"name":"Clinical Neurosurgery Service Centre Hospitalier Universitaire de Lille Roger Salengro Hospital Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-011841"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2421"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000095533"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.12.7042"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-007-9064-y"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01863"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.10.029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020072"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/342034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3743"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/821579"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2007.106.5.833"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2000.93.supplement_3.0006"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000333297.41813.3d"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12938"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-016-2962-6"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2014.09.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2019.10.021"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz503"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa054"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyaa123"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2011.04019.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180111"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2670"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0058-5"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30659-4"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy178"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2772"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.88.6.1002"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2003.05.009"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2018.05.067"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000000425"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30084-0"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.06.2047"},{"key":"e_1_2_10_36_1","first-page":"325","volume-title":"Minimally Invasive Skull Base Surgery: Principles and Practice","author":"Daniel RT","year":"2013"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056444"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056414"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.3.0525"},{"issue":"51","key":"e_1_2_10_40_1","first-page":"107","article-title":"Gamma Knife radiosurgery in pituitary adenomas: why, who, and how to treat?","volume":"10","author":"Castinetti F","year":"2010","journal-title":"Discov Med"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.8.GKS10959"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0733"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.7.GKS101049"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.JNS142013"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyz547"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009314551441"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09553009314551431"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331173"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T06:22:59Z","timestamp":1693635779000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,10]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cen.14346"],"URL":"https:\/\/doi.org\/10.1111\/cen.14346","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,10]]},"assertion":[{"value":"2020-06-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}