{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:51:46Z","timestamp":1747183906939,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late\u2010maturing adolescents grow slower than postulated by age\u2010related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity references for CDGP are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>Here, we provide height velocity data for late\u2010maturing boys based on mixed longitudinal and cross\u2010sectional observations in a group of 38 German adolescents with proven CDGP and compare them with cross\u2010sectional observations in a group of 164 adolescents with organic GHD from the National Cooperative Growth Study registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the critical age interval from 13.4 to 14.9\u00a0years, the growth of prepubertal adolescents with CDGP was faster (mean\/median height velocity, 5.2\/5.4\u00a0cm\/years; quartiles, 4.4\u20106.2\u00a0cm\/years) than that of prepubertal adolescents with organic GHD (3.5\/3.2\u00a0cm\/years; quartiles, 2.0\u20104.4\u00a0cm\/years) in the cross\u2010sectional analysis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0001). Based on our mixed longitudinal and cross\u2010sectional analysis, the height velocity of adolescent boys with CDGP exceeded previous model calculations on average by 1.0\u00a0cm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In conclusion, prepubertal adolescents with CDGP grow faster than patients with organic GHD. Previous model estimates underestimated height velocity of boys with CDGP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14358","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T21:01:24Z","timestamp":1603918884000},"page":"237-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7988-3587","authenticated-orcid":false,"given":"Gerhard","family":"Binder","sequence":"first","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa J.","family":"Lehrian","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology University Children's Hospital  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine Vestische Hospital for Children and Adolescents Datteln University of Witten\/Herdecke  Witten Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar","family":"Blumenstock","sequence":"additional","affiliation":[{"name":"Institute of Clinical Epidemiology and Applied Biostatistics University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelkader","family":"Rahmaoui","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Trzaskoma","sequence":"additional","affiliation":[{"name":"Genentech, Inc.  South San Francisco CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-1834","authenticated-orcid":false,"given":"Thomas","family":"Reinehr","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine Vestische Hospital for Children and Adolescents Datteln University of Witten\/Herdecke  Witten Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1598"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70117-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053245"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14048"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499712"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80501-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.67.10.1277"},{"key":"e_1_2_9_9_1","first-page":"19","article-title":"Growth regulation and the genetics of growth","volume":"200","author":"Tanner JM","year":"1985","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/03014460.2010.521193"},{"key":"e_1_2_9_11_1","unstructured":"NeuheuserH SchienkiewitzA Schaffrath RosarioA DortschyR KurthB.Referenzperzentile f\u00fcr anthropometrische Ma\u00dfzahlen und Blutdruck aus der Studie zur Gesundheit von Kindern und Jugendlichen in Deutschland (KiGGS).www.rkide\/DE\/Content\/Gesundheitsmonitoring\/Gesundheitsberichterstattung\/GBEDownloadsB\/KiGGS_Referenzperzentilepdf?__blob=publicationFile.2013. 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