{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:24:00Z","timestamp":1779297840177,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013733","name":"Ipsen Biopharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013733","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obstructive sleep apnoea (OSA) is reported to have effects on a number of hormone systems including the hypothalamo\u2010pituitary axis. We aimed to determine the impact of OSA severity on insulin\u2010like growth factor\u2010I (IGF\u2010I) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Methods<\/jats:title><jats:p>This is a prospective cohort study performed between November 2014 and May 2017. IGF\u2010I was measured on serum samples, and data were collected on demographics, BMI and parameters of OSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>611 participants were recruited (202 female, 53.5\u00a0\u00b1\u00a012.5\u00a0years; mean BMI 36.2\u00a0\u00b1\u00a08.0\u00a0kg\/m<jats:sup>2<\/jats:sup>). 26.2% had mild OSA; 27.3%, moderate OSA; and 44.5%, severe OSA. 15.2% of IGF\u2010I values were below the age\u2010related reference range. Increasing BMI correlated with greater AHI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.28, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), ODI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.30, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), severity of OSA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.17, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), duration with oxygen saturation (SaO<jats:sub>2<\/jats:sub>) &lt;90% (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.29, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) and reduced median SaO<jats:sub>2<\/jats:sub> levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.19, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). IGF\u2010I levels correlated negatively with age (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.13, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001), BMI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.16, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), diabetes (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.108, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), AHI (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u20100.10, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.043) and severity of OSA (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.10, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.013). No association of IGF\u2010I was observed with ODI, median SaO<jats:sub>2<\/jats:sub> levels or duration of SaO<jats:sub>2<\/jats:sub>\u00a0&lt;\u00a090%. Regression analyses were used to examine determinants of IGF\u2010I, all of which contained the independent variables of age, gender and BMI. All models showed IGF\u2010I to be predicted by age and BMI (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05); however, none of the parameters of OSA were significant within these models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Insulin\u2010like growth factor\u2010I levels in OSA are dependent on age and BMI; however, no additional effect of any OSA parameter was observed, supporting the hypothesis that OSA effects on IGF\u2010I are indirect through concomitant body composition and metabolic parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14360","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T09:04:34Z","timestamp":1604135074000},"page":"434-442","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The severity of obstructive sleep apnoea does not influence ambient IGF\u2010I levels"],"prefix":"10.1111","volume":"94","author":[{"given":"Julie","family":"Lynch","sequence":"first","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology Leeds Teaching Hospitals NHS Trust Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6414-5629","authenticated-orcid":false,"given":"Nikolaos","family":"Kyriakakis","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds Centre for Diabetes &amp; Endocrinology Leeds Teaching Hospitals NHS Trust Leeds UK"},{"name":"Division of Cardiovascular and Diabetes Research Leeds Institute of Cardiovascular and Metabolic Medicine (LICAMM) University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-4155","authenticated-orcid":false,"given":"Khyatisha","family":"Seejore","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Leeds 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