{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:09:18Z","timestamp":1771924158526,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Random growth hormone (GH) levels have been used in the neonate to investigate congenital growth hormone deficiency (GHD). The cut\u2010off value for use in this diagnosis is yet to be established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective chart review of all random GH levels obtained in neonates \u226428\u00a0days of age. Neonates were divided into three groups: those diagnosed with congenital GHD, those at risk for GHD (ARF\u2010GHD) and a non\u2010growth hormone deficient (non\u2010GHD) group. Mean GH levels for each group were compared, and ROC analysis was used to identify a cut\u2010off for the diagnosis of GHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 138 neonates with the mean age of 9.07\u00a0\u00b1\u00a06.6\u00a0days, and 65% of these were born at term gestation. Mean GH levels were lower in the GHD group (2.73\u00a0\u00b1\u00a01.19\u00a0ng\/ml) as compared to the ARF\u2010GHD (9.4\u00a0\u00b1\u00a07.96\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) and non\u2010GHD groups (14.86\u00a0\u00b1\u00a014.42\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027). GH values were not significantly different between non\u2010GHD and ARF\u2010GHD groups. ROC analysis identified a cut\u2010off of serum random GH level of 4.5\u00a0ng\/ml that achieved 100% sensitivity and 83% specificity for the diagnosis of congenital GHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that random GH levels obtained in the first 28\u00a0days of life can be useful in diagnosing congenital GHD. Moreover, a diagnostic cut\u2010off for congenital GHD using random GH levels was identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14364","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T14:45:41Z","timestamp":1604414741000},"page":"392-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The utility of a random growth hormone level in determining neonatal growth hormone sufficiency"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8782-7454","authenticated-orcid":false,"given":"Leena","family":"Mamilly","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Pyle\u2010Eilola","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Nationwide Children's Hospital Columbus OH USA"},{"name":"Department of Pathology The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Chaudhari","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine Columbus OH USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4514-2702","authenticated-orcid":false,"given":"Rohan K.","family":"Henry","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Pediatrics Nationwide Children's Hospital The Ohio State University College of Medicine Columbus OH 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