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Recent advances in genetics have greatly enhanced understanding of the pathogenesis and molecular physiology of PPGL. Concomitantly, advances in molecular imaging mean four techniques are now available for use in PPGLs: [<jats:sup>123<\/jats:sup>I]\u2010MIBG coupled with SPECT\/CT; [<jats:sup>18<\/jats:sup>F]\u2010 FDG, [<jats:sup>68<\/jats:sup>Ga]\u2010DOTATATE and [<jats:sup>18<\/jats:sup>F]\u2010FDOPA coupled with PET\/CT. Each modality relies on unique cellular uptake mechanisms that are contingent upon the tumour's molecular behaviour\u2014which, in turn, is determined by the tumour's genetic profile. This genotype\u2010phenotype correlation means the appropriate choice of radiotracer may depend on the known (or suspected) underlying genetic mutation, in addition to the clinical indication for the scan\u2014whether confirming diagnosis, staging disease, surveillance or determining eligibility for radionuclide therapy. Given these rapid recent changes in genetic understanding and molecular imaging options, many clinicians find it challenging to choose the most appropriate scan for an individual with PPGL. To this end, recent guidelines published by the European Association of Nuclear Medicine and the Society of Nuclear Medicine and Molecular Imaging (EANM\/SNMMI) have detailed the preferred radiotracer choices for individuals with PPGL based on their genotype and\/or clinical presentation, providing timely clarity in this rapidly moving field. The current review summarizes the implications of the genotype\u2010phenotype relationship of PPGL, specifically relating this to the performance of molecular imaging modalities, to inform and enable practising endocrinologists to provide tailored, personalized care for individuals with PPGL.<\/jats:p>","DOI":"10.1111\/cen.14375","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T18:02:36Z","timestamp":1607623356000},"page":"13-28","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["PET detectives: Molecular imaging for phaeochromocytomas and paragangliomas in the genomics era"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-8612","authenticated-orcid":false,"given":"Simon J.","family":"Ryder","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Brisbane and Women's Hospital Herston Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda J.","family":"Love","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Diabetes Royal Brisbane and Women's Hospital Herston Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8143-4403","authenticated-orcid":false,"given":"Emma L.","family":"Duncan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland Brisbane Australia"},{"name":"Professor of Clinical Endocrinology Department of Twin Research &amp; Genetic Epidemiology School of Life Course Sciences Faculty of Life Sciences and Medicine King\u2019s College London London UK"},{"name":"The Department of Endocrinology St Thomas\u2019 Hospital Guy\u2019s and St Thomas\u2019 NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9718-5598","authenticated-orcid":false,"given":"David A.","family":"Pattison","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Queensland Brisbane Australia"},{"name":"Department of Nuclear Medicine &amp; Specialised PET Services Royal Brisbane and Women's Hospital Herston Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-017-9484-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-15-0175"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-017-0786-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1986.tb02755.x"},{"issue":"12","key":"e_1_2_11_6_1","first-page":"802","article-title":"Occurrence of pheochromocytoma in Rochester, Minnesota, 1950 through 1979","volume":"58","author":"Beard CM","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.01.015"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199405000-00015"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.6.3.249"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.27.193"},{"issue":"2","key":"e_1_2_11_12_1","first-page":"637","article-title":"A survey on adrenal incidentaloma in Italy. 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