{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T03:34:11Z","timestamp":1792467251756,"version":"4.5.0"},"reference-count":149,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Secondary oligo\/amenorrhoea occurs in 3%\u20135% of women of reproductive age. The two most common causes are polycystic ovary syndrome (PCOS) (2%\u201313%) and functional hypothalamic amenorrhoea (FHA) (1%\u20132%). Whilst both conditions have distinct pathophysiology and their diagnosis is supported by guidelines, in practice, differentiating these two common causes of menstrual disturbance is challenging. Moreover, both diagnoses are qualified by the need to first exclude other causes of menstrual disturbance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review clinical, biochemical and radiological parameters that could aid the clinician in distinguishing PCOS and FHA as a cause of menstrual disturbance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FHA is uncommon in women with BMI\u00a0&gt;\u00a024\u00a0kg\/m<jats:sup>2<\/jats:sup>, whereas both PCOS and FHA can occur in women with lower BMIs. AMH levels are markedly elevated in PCOS; however, milder increases may also be observed in FHA. Likewise, polycystic ovarian morphology (PCOM) is more frequently observed in FHA than in healthy women. Features that are differentially altered between PCOS and FHA include LH, androgen, insulin, AMH and SHBG levels, endometrial thickness and cortisol response to CRH. Other promising diagnostic tests with the potential to distinguish these two conditions pending further study include assessment of 5\u2010alpha\u2010reductase activity, leptin, INSL3, kisspeptin and inhibin B levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Further data directly comparing the discriminatory potential of these markers to differentiate PCOS and FHA in women with secondary amenorrhoea would be of value in defining an objective probability for PCOS or FHA diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14402","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T12:39:20Z","timestamp":1608813560000},"page":"239-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Clinical and biochemical discriminants between functional hypothalamic amenorrhoea (FHA) and polycystic ovary syndrome (PCOS)"],"prefix":"10.1111","volume":"95","author":[{"given":"Maria","family":"Phylactou","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Clarke","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijal","family":"Patel","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Baggaley","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2578-8223","authenticated-orcid":false,"given":"Channa N.","family":"Jayasena","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"},{"name":"Department of Endocrinology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8091-1458","authenticated-orcid":false,"given":"Tom W.","family":"Kelsey","sequence":"additional","affiliation":[{"name":"School of Computer Science University of St Andrews St Andrews UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander N.","family":"Comninos","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"},{"name":"Department of Endocrinology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-4316","authenticated-orcid":false,"given":"Waljit S.","family":"Dhillo","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"},{"name":"Department of Endocrinology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2795-5256","authenticated-orcid":false,"given":"Ali","family":"Abbara","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Investigative Medicine Hammersmith Hospital Imperial College London London UK"},{"name":"Department of Endocrinology Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-00131"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"},{"key":"e_1_2_11_5_1","volume-title":"Diagnostic and Statistical Manual of Mental Health Disorders: DSM\u20105","author":"American Psychiatric Association","year":"2015"},{"issue":"11","key":"e_1_2_11_6_1","first-page":"1049","article-title":"Functional hypothalamic amenorrhea and its influence on women's health","volume":"37","author":"Meczekalski B","year":"2014","journal-title":"Acad Psychiatry"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e318149f111"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12666"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-8-41"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2012-0047"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.37.6.490"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-016-0260-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2011.06.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1996.270.1.E1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.22697"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0033930"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep411"},{"key":"e_1_2_11_19_1","first-page":"1","article-title":"Recovery of menses after functional hypothalamic amenorrhoea: if, when and why","author":"Pape J","year":"2020","journal-title":"Hum Reprod Update"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1997.02170380020003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.10.2198"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4172\/2470-7570.1000116"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00649.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.08.018"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16379-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2501"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjsm.36.1.10"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmz020"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.02.006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.04.067"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1992.tb02262.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2008.09.016"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.01850"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1500363"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3999(94)90059-0"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00601-9"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/02646838.2016.1278201"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(03)01124-5"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318202b0a4"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex044"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep031"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.03.028"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05499-1"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.03.027"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2016.08.005"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1494"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007813"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0911064"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa609"},{"issue":"1","key":"e_1_2_11_50_1","first-page":"141","article-title":"The heritability of eating disorders: methods and current findings","volume":"6","author":"Thornton LM","year":"2011","journal-title":"Curr Top Behav Neurosci"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-185"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-61-3-557"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53693-0"},{"issue":"6","key":"e_1_2_11_54_1","first-page":"1905","article-title":"Neuroendocrine abnormalities in hypothalamic amenorrhea: spectrum, stability, and response to neurotransmitter modulation","volume":"84","author":"Perkins RB","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.6.1156"},{"issue":"8","key":"e_1_2_11_56_1","first-page":"2854","article-title":"Insulin, somatotropic, and luteinizing hormone axes in lean and obese women with polycystic ovary syndrome: common and distinct features","volume":"81","author":"Morales AJ","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"e_1_2_11_57_1","first-page":"3728","article-title":"Inappropriate gonadotropin secretion in polycystic ovary syndrome: influence of adiposity 1","volume":"82","author":"Arroyo A","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0780625"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-43-1-159"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0800417"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03327602"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.01945.x"},{"issue":"2","key":"e_1_2_11_63_1","first-page":"120","article-title":"The utility of the gonadotrophin releasing hormone (GnRH) test in the diagnosis of polycystic ovary syndrome (PCOS)","volume":"62","author":"Lewandowski KC","year":"2011","journal-title":"Endokrynol Polska"},{"issue":"6","key":"e_1_2_11_64_1","first-page":"847","article-title":"Women with oligo\u2010\/amenorrhoea and polycystic ovaries have identical responses to GnRH stimulation regardless of their androgen status: comparison of the Rotterdam and Androgen excess society diagnostic criteria","volume":"32","author":"Lewandowski KC","year":"2011","journal-title":"Neuroendocrinol Lett"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2004.05.004"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa116"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0655"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13934"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1395842"},{"issue":"1","key":"e_1_2_11_70_1","first-page":"25","article-title":"Nutritional and endocrine\u2010metabolic aberrations in women with functional hypothalamic amenorrhea","volume":"83","author":"Laughlin GA","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"e_1_2_11_71_1","first-page":"1","article-title":"Determinants of growth hormone resistance in malnutrition","volume":"220","author":"Fazeli PAK","year":"2015","journal-title":"J Endocrinol"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00634-2"},{"key":"e_1_2_11_73_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2019.00656","article-title":"Anti\u2010m\u00fcllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome","volume":"10","author":"Abbara A","year":"2019","journal-title":"Front Endocrinol"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1393"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.12.055"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.004"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.01.007"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.02.005"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92552-8"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1836"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)91612-1"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei159"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaa012"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh560"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00442.x"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(00)00421-0"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02481-4"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1609-1"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2016.09.032"},{"key":"e_1_2_11_90_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00298"},{"key":"e_1_2_11_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.04.018"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.11.019"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53719-4"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(75)90475-5"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(96)00016-6"},{"issue":"6","key":"e_1_2_11_96_1","first-page":"1040","article-title":"Factors associated with withdrawal bleeding after administration of oral micronized progesterone in women with secondary amenorrhea","volume":"56","author":"Shangold M","year":"1991","journal-title":"Gynecol Endocrinol"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)54182-X"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2488-y"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.01.023"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12062"},{"issue":"1","key":"e_1_2_11_101_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12891\/ceog4531.2019","article-title":"Investigation of the endometrial thickness and estrogen level in athletes and sedentaries","volume":"46","author":"Gen\u00e7 A","year":"2019","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmy007"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des463"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-65-3-499"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.08.035"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.8.2043"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(98)00044-7"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90202-4"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2422"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-50-1-113"},{"key":"e_1_2_11_111_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.012666"},{"key":"e_1_2_11_112_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0242-9"},{"key":"e_1_2_11_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021875"},{"key":"e_1_2_11_114_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719116670265"},{"key":"e_1_2_11_115_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2010.487586"},{"key":"e_1_2_11_116_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040388"},{"key":"e_1_2_11_117_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-2-311"},{"key":"e_1_2_11_118_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-66-4-733"},{"key":"e_1_2_11_119_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-2-402"},{"key":"e_1_2_11_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)57596-7"},{"key":"e_1_2_11_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.12.023"},{"key":"e_1_2_11_122_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1678"},{"issue":"4","key":"e_1_2_11_123_1","first-page":"279","article-title":"Ultrasonographic study of ovaries of 19 women with weight loss\u2010related hypothalamic oligo\u2010amenorrhea","volume":"42","author":"Futterweit W","journal-title":"Biomed Pharmacother"},{"key":"e_1_2_11_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.05.063"},{"key":"e_1_2_11_125_1","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2019-0640"},{"key":"e_1_2_11_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12647"},{"key":"e_1_2_11_127_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1716"},{"key":"e_1_2_11_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2007.02.063"},{"key":"e_1_2_11_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-016-0159-8"},{"key":"e_1_2_11_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den239"},{"key":"e_1_2_11_131_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2698"},{"key":"e_1_2_11_132_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del457"},{"key":"e_1_2_11_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.149"},{"key":"e_1_2_11_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.09.003"},{"key":"e_1_2_11_135_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0932"},{"key":"e_1_2_11_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.017"},{"key":"e_1_2_11_137_1","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2007.113"},{"key":"e_1_2_11_138_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den430"},{"key":"e_1_2_11_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-8-53"},{"key":"e_1_2_11_140_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.613972"},{"key":"e_1_2_11_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.051"},{"key":"e_1_2_11_142_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8195"},{"key":"e_1_2_11_143_1","first-page":"407","article-title":"Body composition characteristics, sex hormone levels and circadian gonadotropin fluctuations in infertile young women","volume":"23","author":"Kirchengast S","year":"1999","journal-title":"Collegium Antropol"},{"key":"e_1_2_11_144_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02533.x"},{"key":"e_1_2_11_145_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030727"},{"key":"e_1_2_11_146_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030932"},{"key":"e_1_2_11_147_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.4.746"},{"key":"e_1_2_11_148_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500098125"},{"issue":"1","key":"e_1_2_11_149_1","first-page":"275","article-title":"Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome","volume":"101","author":"Shayya RF","year":"2014","journal-title":"J Invest Dermatol"},{"key":"e_1_2_11_150_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.579664"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14402","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14402","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T04:23:36Z","timestamp":1693196616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":149,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/cen.14402"],"URL":"https:\/\/doi.org\/10.1111\/cen.14402","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}