{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:09:25Z","timestamp":1781276965880,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Measurement of hypertonic saline\u2010stimulated copeptin has recently been described for the differentiation of polyuria\u2010polydipsia syndrome. This study aims to determine the copeptin response to intravenous 3% hypertonic saline, including evaluation of adverse effects, in a local cohort of healthy adults &gt;18\u00a0years in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Prospective clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty healthy volunteers (10 males and 10 females) were recruited. Participants underwent infusion of 3% hypertonic saline via a previously described standardized protocol, until the plasma sodium was \u2265150\u00a0mmol\/L, with measurement of plasma copeptin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean peak sodium was 152\u00a0mmol\/L\u00a0\u00b1\u00a0SD 1.4 with osmolality 315\u00a0mmol\/kg\u00a0\u00b1\u00a0SD 3.9. Median volume of hypertonic saline infused to reach target sodium\u00a0\u2265\u00a0150\u00a0mmol\/L was 1536\u00a0mL (IQR 1362, 1992). Mean rate of plasma sodium rise was 5.9\u00a0mmol\/L\/hour\u00a0\u00b1\u00a0SD 1.5. Hypertonic saline\u2010stimulated copeptin had non\u2010parametrical distribution with median of 33.8\u00a0pmol\/L (IQR 27.6, 63.6). Overall median symptom burden was 6\/10 (range 3\/10\u20109\/10). Copeptin was significantly higher for those who experienced nausea and\/or vomiting (n\u00a0=\u00a013) (median 39.0\u00a0pmol\/L; IQR 32.5, 90), compared to those participants who did not experience either (median 20.0\u00a0pmol\/L; IQR 13.0, 31.0) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). There were no serious adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Hypertonic saline\u2010stimulated copeptin measurements were similar in our population compared with previously reported reference intervals in healthy volunteers. There is a wide range of stimulated copeptin measurements in the healthy population. Nausea and vomiting are common adverse effects which enhance the copeptin response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14417","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T21:09:30Z","timestamp":1610744970000},"page":"820-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Copeptin is increased by nausea and vomiting during hypertonic saline infusion in healthy individuals"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3513-8125","authenticated-orcid":false,"given":"Emily","family":"Brooks","sequence":"first","affiliation":[{"name":"Department of Diabetes and Endocrinology Princess Alexandra Hospital Brisbane Australia"},{"name":"Faculty of Medicine University of Queensland Brisbane 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