{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:49Z","timestamp":1759336309686,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010438","name":"Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu","doi-asserted-by":"publisher","award":["Student Research Grant No. 225"],"award-info":[{"award-number":["Student Research Grant No. 225"]}],"id":[{"id":"10.13039\/501100010438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Interleukins play an important role in the development of autoimmune disorders. The aim of this study was to compare the concentration of interleukin\u201029 (IL\u201029) between healthy controls (CS) and patients with selected thyroid disorders: Graves\u2019 disease (GD), Hashimoto's thyroiditis (HT) and subacute thyroiditis (SAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and methods<\/jats:title><jats:p>The following parameters were examined in the group of 95 individuals (45 with GD, 22 with HT, 28 with SAT) and 72 CS: thyroid hormones and autoantibodies, inflammatory markers and the concentration of IL\u201029 in serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of IL\u201029 in the GD subgroup was higher than that in the CS subgroup [264.0 (62.5\u20101018.0) vs. 62.5 (62.5\u2010217.0) pg\/mL, <jats:italic>P\u00a0<\/jats:italic>=\u00a0.001]. We found no differences in IL\u201029 concentrations between the CS and HT or SAT subgroups. Multivariable linear regression analysis indicated that IL\u201029 was a statistically significant independent predictor of GD presence (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.24; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003) after adjustment for TRAb (<jats:italic>R<\/jats:italic><jats:sup>2\u00a0<\/jats:sup>=\u00a00.45; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The ROC analysis of IL\u201029 at GD diagnosis revealed an IL\u201029 cut\u2010off of 123\u00a0pg\/mL (sensitivity: 0.689 and specificity: 0.625) as the best value, which significantly indicated the presence of GD [area under the ROC curve (AUC): 0.676; 95% confidence interval (CI): 0.574\u20100.778, <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a0.001].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first study to demonstrate elevated IL\u201029 serum levels in patients with GD. Our results suggest that IL\u201029 might be engaged in one of the pathogenetic pathways of GD, but no HT and SAT. Future studies are required to evaluate the potential of the protein as a therapeutic target in GD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14418","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:22:42Z","timestamp":1610756562000},"page":"998-1003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluation of interleukin\u201029 in autoimmune and inflammatory thyroid diseases"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-260X","authenticated-orcid":false,"given":"Bogusz","family":"Falkowski","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-3274","authenticated-orcid":false,"given":"Ewelina","family":"Szczepanek\u2010Parulska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Krygier","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzbieta","family":"Wrotkowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-7220","authenticated-orcid":false,"given":"Marek","family":"Ruchala","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Medicine Poznan University of Medical Sciences Poznan Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11111024"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.001"},{"issue":"112","key":"e_1_2_12_4_1","first-page":"31","article-title":"Increased expression of interferon\u2010lambda in minor salivary glands of patients with primary Sjogren's syndrome and its synergic effect with interferon\u2010alpha on salivary gland epithelial cells","volume":"36","author":"Ha YJ","year":"2018","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.241.89"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1054028"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006245"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1878-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12809"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/self.2.2.16939"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.04.002"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2010.0078"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12470"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3428236"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2016.1208215"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510030"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/979167"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-5"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03344951"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2019.0018"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5764061"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9010198"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.08.002"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.917299"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9631510"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430330"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064277"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-011-0364-z"},{"key":"e_1_2_12_30_1","first-page":"8363","article-title":"Interleukin 29 activates expression of tissue inhibitor of metalloproteinase 1 in macrophages via toll\u2010like receptor 2","volume":"17","author":"Zhang H","year":"2018","journal-title":"Mol Med Rep"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00578"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364382"},{"key":"e_1_2_12_33_1","first-page":"28","article-title":"Disturbed Th1 and Th2 balance in patients with Graves' disease","volume":"41","author":"Eshaghkhani Y","year":"2016","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/08916934.2019.1698553"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3011"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3A0215-041RR"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14697"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364348"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9240-9"},{"key":"e_1_2_12_40_1","first-page":"122","article-title":"The relationship between intrathyroidal dendritic cells and humoral immune disorder in Graves' disease","volume":"44","author":"Zhang HJ","year":"2005","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092849"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4935"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2008.02862.x"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14418","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14418","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:40:21Z","timestamp":1693586421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,28]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/cen.14418"],"URL":"https:\/\/doi.org\/10.1111\/cen.14418","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"type":"print","value":"0300-0664"},{"type":"electronic","value":"1365-2265"}],"subject":[],"published":{"date-parts":[[2021,1,28]]},"assertion":[{"value":"2020-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}