{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T15:30:37Z","timestamp":1780759837898,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of the study was the quantification of circulating tumour cells (CTCs) in differentiated thyroid cancer (DTC) patients before and 6\u00a0weeks after radioiodine therapy (RIT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Context<\/jats:title><jats:p>Circulating tumour cells (CTCs) were described more recently in cancer patients, mostly correlating with poor outcome and advanced metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Peripheral blood for identification and quantification of CTC before RIT or\/and 6\u00a0weeks after RIT was provided by 55 DTC patients that received RIT for remnant tissue ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>13 follicular thyroid cancer (FTC) patients, 31 papillary thyroid cancer (PTC) patients and 11 patients having the follicular variant PTC (FV\u2010PTC) were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Peripheral blood mononuclear cells (PBMCs) were isolated and EpCAM\u2010positive CTCs were counted by immune fluorescent staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A CTC positivity of 31.8% before RIT could be observed. Six weeks after RIT, the CTC positivity was reduced to 13.6%. Paired data at both time points of blood sampling could be gathered for n\u00a0=\u00a033 DTC patients. These patients had significantly higher CTC numbers before RIT than 6\u00a0weeks afterwards (0.27\u00a0\u00b1\u00a00.47 vs 0.05\u00a0\u00b1\u00a00.15, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0215). Additionally, significantly reduced CTC numbers were also demonstrated in pre\u2010RIT CTC\u2010positive patients (0.88\u00a0\u00b1\u00a00.43 vs 0.05\u00a0\u00b1\u00a00.16, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate a reducing effect on the number of CTCs by RIT. Therefore, CTC enumeration should be considered as efficient tool for treatment monitoring during RIT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14419","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T11:36:57Z","timestamp":1611401817000},"page":"1004-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Radioiodine therapy reduces the frequency of circulating tumour cells in patients with differentiated thyroid cancer"],"prefix":"10.1111","volume":"94","author":[{"given":"Mathias","family":"Schmidt","sequence":"first","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Antke","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine University Hospital Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Mattes\u2010Gy\u00f6rgy","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine University Hospital Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubertus","family":"Hautzel","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine University Hospital Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Allelein","sequence":"additional","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Haase","sequence":"additional","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Dringenberg","sequence":"additional","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Schott","sequence":"additional","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0045-6337","authenticated-orcid":false,"given":"Margret","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Division for Specific Endocrinology Medical Faculty University of Duesseldorf Duesseldorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12488-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-2458"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/105072503322511355"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.12811.1"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-4332"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343973"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0160"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1740"},{"key":"e_1_2_10_10_1","first-page":"256","article-title":"Circulating tumour cells in thyroid carcinoma \u2010 the prognostic role of this biomarker. 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