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Vetenskaps- och Vitterhets-Samh\u00e4llet i G\u00f6teborg","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005689","name":"G\u00f6teborgs L\u00e4kares\u00e4llskap","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005689","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010107","name":"Anna-Lisa och Bror Bj\u00f6rnssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010107","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Somatostatin receptors (SSTRs) are potential targets for detecting pituitary neuroendocrine tumours (PitNETs) that can be visualized effectively with <jats:sup>68<\/jats:sup>Ga\u2010labelled PET tracers. With this study, we have evaluated the diagnostic properties of such a tracer, <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC, in patients with hormone\u2010producing PitNETs before and after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design\/Methods<\/jats:title><jats:p>This prospective case\u2010control study presents preoperative positron emission tomography (PET) and histopathological data in 18 patients with somatotroph (<jats:italic>n<\/jats:italic>\u00a0=\u00a08), corticotroph (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) and thyrotroph (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) PitNETs. Patients were scanned pre\u2010 and postoperatively with <jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET. For the postoperative part of the study, patients with gonadotroph tumours (<jats:italic>n<\/jats:italic>\u00a0=\u00a07) were also included. Fifteen pituitary healthy controls underwent the same protocol once. The maximum standard uptake value (SUV<jats:sub>max<\/jats:sub>) was analysed in manually outlined regions around the tumour in patients and around the pituitary gland in controls. specimens were collected during surgery in subjects for assessment of adenohypophyseal tumour cell type and the SSTR expression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thyrotroph tumours showed higher uptake (median SUV<jats:sub>max<\/jats:sub> 41.1; IQR 37.4\u201060.0) and corticotroph tumours lower uptake (SUV<jats:sub>max<\/jats:sub> 6.8; 2.6\u20109.3) than normal pituitary gland (SUV<jats:sub>max<\/jats:sub> 13.8; 12.1\u201015.5). The uptake in somatotroph tumours (SUV<jats:sub>max<\/jats:sub> 15.9; 11.6\u201019.7) was similar to the uptake in the pituitary gland. There was a strong correlation between SUV<jats:sub>max<\/jats:sub> and SSTR2 expression (r\u00a0=\u00a0.75 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01)). In the postoperative evaluation, PET was able to correlate tracer uptake with biochemical cure and noncure in patients with an abnormal postoperative magnetic resonance image and a preoperative tumour uptake SUV<jats:sub>max<\/jats:sub>\u00a0&gt;\u00a013.8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:sup>68<\/jats:sup>Ga\u2010DOTATOC PET can be used to detect thyrotroph tumours in the pre\u2010 and postoperative imaging assessment. Corticotroph tumours had a significantly lower uptake compared to the pituitary gland but without a distinct increased tumour uptake the clinical postoperative value is limited.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14425","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T11:40:17Z","timestamp":1611402017000},"page":"956-967","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pre\u2010 and postoperative <sup>68<\/sup>Ga\u2010DOTATOC positron emission tomography for hormone\u2010secreting pituitary neuroendocrine tumours"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5622-7744","authenticated-orcid":false,"given":"Axel","family":"Tj\u00f6rnstrand","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Clinical Nutrition Institute of Medicine Sahlgrenska Academy University of Gothenburg G\u00f6teborg 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M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7800-1781","authenticated-orcid":false,"given":"Michael","family":"Sch\u00f6ll","sequence":"additional","affiliation":[{"name":"Wallenberg Centre for Molecular and Translational Medicine Sahlgrenska University Hospital G\u00f6teborg Sweden"},{"name":"Institute of Neuroscience and Physiology Department of Psychiatry and Neurochemistry University of Gothenburg G\u00f6teborg Sweden"},{"name":"Dementia Research Centre Queen Square Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Gjertsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Sahlgrenska University Hospital G\u00f6teborg Sweden"},{"name":"Department of Molecular and Clinical Medicine Institute of Medicine Sahlgrenska Academy University of Gothenburg G\u00f6teborg 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