{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:25:57Z","timestamp":1785209157354,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although renal impairments are observed in patients with primary aldosteronism (PA), the association between plasma aldosterone concentration (PAC) and specific structural kidney damage remains unknown. Thus, we analysed the association between PAC, and markers of glomerular and tubular damage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>This was a retrospective cross\u2010sectional study of 96 PA patients, in which we analysed the association between PAC and markers of kidney damage, including urinary albumin\u2010creatinine ratio (ACR) for glomerular damage, and urinary liver fatty acid\u2010binding protein (L\u2010FABP), N\u2010acetyl\u2010\u03b2\u2010D\u2010glucosaminidase (NAG) and \u03b22\u2010microglobulin (\u03b22\u2010MG) for tubular damage. In addition, we evaluated the association between PAC and N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP) as a marker for body fluid volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Urinary ACR, L\u2010FABP, NAG, \u03b22\u2010MG and NT\u2010proBNP significantly correlated with PAC. PAC (&lt;415\u00a0pmol\/L, 415\u2010550, 550\u2010740, 740 &lt;)\u2010based quartile analysis revealed that both elevated markers of kidney damage and NT\u2010proBNP could be observed in PA patients with a PAC over 550\u00a0pmol\/L. Logistic regression analysis showed that PAC was significantly associated with a risk of both microalbuminuria and lowered eGFR (&lt;60\u00a0mL\/min\/1.73\u00a0m<jats:sup>2<\/jats:sup>), with its optimal cut\u2010offs for predicting each, 558 and 594\u00a0pmol\/L, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased PAC, especially over 550\u00a0pmol\/L, is associated with excessive damage to the tubule and glomerulus.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14434","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T15:20:41Z","timestamp":1612624841000},"page":"920-926","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Association between plasma aldosterone and markers of tubular and glomerular damage in primary aldosteronism"],"prefix":"10.1111","volume":"94","author":[{"given":"Yoshihiro","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-0374","authenticated-orcid":false,"given":"Hiroki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine Nihon University School of Medicine Tokyo Japan"},{"name":"Section on Genetics and Epidemiology, Research Division Joslin Diabetes Center Boston MA USA"},{"name":"Department of Medicine Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Hypertension and Endocrinology, Department of Internal Medicine Nihon University School of Medicine Tokyo 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