{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:27:36Z","timestamp":1783474056595,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Acromegaly is associated with increased vertebral fracture (VFs) risk not correlated to bone mineral density (BMD). Trabecular bone score (TBS), related to bone microarchitecture, provides information on bone strength. This cross\u2010sectional study considered the usefulness of TBS and BMD to assess bone status in long\u2010term controlled acromegalic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, patients, measurements<\/jats:title><jats:p>26 acromegaly patients (14 female and 12 males) were included in the study. A further 117 subjects were recruited as controls (58 females and 57 males). BMD was measured using dual\u2010energy X\u2010ray absorptiometry (DXA), TBS was obtained applying Medimaps software 2.0. Biochemical parameters were determined by standardized techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>73% of patients with acromegaly exhibited normal lumbar spine (LS) BMD. TBS was normal in 38% of acromegalic patients and partially degraded or degraded in 31% of patients, respectively. No differences were found in LS BMD between acromegalic patients and controls. TBS values were significantly lower in patients with acromegaly (1.27\u00a0\u00b1\u00a00.13 vs. 1.35\u00a0\u00b1\u00a00.17, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). Postsurgical remission was associated with higher TBS values (1.35\u00a0\u00b1\u00a00.10 vs. 1.23\u00a0\u00b1\u00a00.13, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and pituitary radiotherapy treatment with lower TBS values (1.18\u00a0\u00b1\u00a00.12 vs. 1.31\u00a0\u00b1\u00a00.12, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). On multivariate analysis, age, BMI and LS BMD were predictors of TBS changes in patients with acromegaly (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with long\u2010term controlled acromegaly can exhibit deterioration of bone microstructure measured with TBS, despite BMD measurement not showing bone loss. Our study suggests that TBS is useful for monitoring the bone status changes in acromegalic patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14439","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T03:51:06Z","timestamp":1612929066000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Trabecular bone score and bone mineral density in patients with long\u2010term controlled acromegaly"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-7289","authenticated-orcid":false,"given":"Mar\u00eda","family":"Calatayud","sequence":"first","affiliation":[{"name":"Endocrinology Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"P\u00e9rez\u2010Olivares Mart\u00edn","sequence":"additional","affiliation":[{"name":"Endocrinology Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Soledad","family":"Librizzi","sequence":"additional","affiliation":[{"name":"Endocrinology Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lora Pablos","sequence":"additional","affiliation":[{"name":"Epidemiology Unit University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Gonz\u00e1lez M\u00e9ndez","sequence":"additional","affiliation":[{"name":"Radiology Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Aramendi Ramos","sequence":"additional","affiliation":[{"name":"Biochemical Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Mart\u00ednez Diaz\u2010Guerra","sequence":"additional","affiliation":[{"name":"Endocrinology Service University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Hawkins","sequence":"additional","affiliation":[{"name":"Research Institute i+12 University Hospital 12 Octubre Faculty of Medicine Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2007-0036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2937"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1391-5"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-567"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0881"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0808"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050603"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0791"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03322.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000375450"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.00944.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2018.02.009"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650090802"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2176"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0468"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4073"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-011-1824-6"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-9980-x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2700"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650080915"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0385"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-4166-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-1005"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-2695"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11102-017-0847-1"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ15-0174"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9486-x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-017-0410-z"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-015-3344-2"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-16-0340"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-18-0881"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00831-3"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2176"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14439","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:51:26Z","timestamp":1693353086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1111\/cen.14439"],"URL":"https:\/\/doi.org\/10.1111\/cen.14439","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,3]]},"assertion":[{"value":"2020-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}