{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:49:39Z","timestamp":1776988179247,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["759161"],"award-info":[{"award-number":["759161"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross\u2010sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Healthy men (<jats:italic>n<\/jats:italic>\u00a0=\u00a034) and women (<jats:italic>n<\/jats:italic>\u00a0=\u00a021) were combined from two cross\u2010sectional studies. Forty\u2010two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DNL was inversely associated with SHBG in women (\u03b2: \u22120.015, 95% CI: \u22120.030; 0.000), but not in men (\u03b2: 0.007, 95% CI: \u22120.005; 0.019) (<jats:italic>p<\/jats:italic> for interaction\u00a0=\u00a0.068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14459","type":"journal-article","created":{"date-parts":[[2021,3,14]],"date-time":"2021-03-14T12:35:10Z","timestamp":1615725310000},"page":"101-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-8330","authenticated-orcid":false,"given":"Pomme I. H. G.","family":"Simons","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands"},{"name":"Laboratory for Metabolism and Vascular Medicine Maastricht University Maastricht The Netherlands"},{"name":"CARIM School for Cardiovascular Diseases Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Valkenburg","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ine","family":"Telgenkamp","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands"},{"name":"Laboratory for Metabolism and Vascular Medicine Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen M.","family":"van der Waaij","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands"},{"name":"Laboratory for Metabolism and Vascular Medicine Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"de Groot","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolic Diseases Department of Internal Medicine Maastricht University Medical Centre Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pandichelvam","family":"Veeraiah","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences Maastricht University Maastricht Netherlands"},{"name":"Department of Radiology and Nuclear Medicine Maastricht University Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A. P.","family":"Bons","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory Maastricht University Medical Centre Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja\u2010Riitta","family":"Taskinen","sequence":"additional","affiliation":[{"name":"Research Program, Unit Clinical and Molecular Metabolism University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Bor\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine University of Gothenburg Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Schrauwen","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Movement Sciences Maastricht University Maastricht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost H. W.","family":"Rutten","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cassiman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology\u2010Hepatology and Metabolic Centre University Hospital Leuven Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper G.","family":"Schalkwijk","sequence":"additional","affiliation":[{"name":"Laboratory for Metabolism and Vascular Medicine Maastricht University Maastricht The Netherlands"},{"name":"CARIM School for Cardiovascular Diseases Maastricht University Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coen D. 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