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The purpose of this narrative review was to summarize available data on predictive factors, both in routine practice and research settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A literature review was conducted for papers published in peer\u2010reviewed journals, investigating clinical, radiological, pathological and genetic predictive factors in NFPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several clinical and radiological factors have been associated with NFPT recurrence and\/or aggressiveness, including larger size and pre\u2010\/post\u2010operative growth rates. Application of transcription factor immunohistochemistry has given rise to improved subtype identification, including \u2018higher\u2010risk\u2019 subtypes, in routine clinical practice. Numerous other pathological and genetic biomarkers have demonstrated promise for prognostication in the research setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NFPT are a heterogenous group of tumours, characterized by diverse presentation, pathogenesis and outcomes. Ongoing refinements in understanding of tumour biology are likely to pave the way to improved integrative prognostication and precision medicine for NFPT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14472","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:45:00Z","timestamp":1616892300000},"page":"398-409","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Towards precision medicine for clinically non\u2010functioning pituitary tumours"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6738-0832","authenticated-orcid":false,"given":"N\u00e8le F.","family":"Lenders","sequence":"first","affiliation":[{"name":"Department of Endocrinology St Vincent's Hospital Sydney New South Wales Australia"},{"name":"Garvan Institute of Medical Research Sydney New South Wales Australia"},{"name":"St Vincent's Clinical School Faculty of Medicine UNSW Sydney New 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