{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:35:39Z","timestamp":1788561339474,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2019\u2010CX\u201017"],"award-info":[{"award-number":["2019\u2010CX\u201017"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["71804025"],"award-info":[{"award-number":["71804025"]}],"id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary aldosteronism (PA) is an underdiagnosed cause of hypertension. Although the medical costs will increase if all patients with elevated blood pressure are screened, the number of missed diagnosed patients with PA and the medical resources subsequently consumed by adverse cardiovascular and cerebrovascular events can be reduced. This study aimed to conduct economic evaluation PA screening strategies in Chinese patients with hypertension, that is PA screening in patients with high\u2010risk hypertension and all patients with hypertension, to determine the cost\u2010effective method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The decision tree and Markov model were constructed using TreeAge Pro 2020. Using the latter, a 30\u2010year course of hypertension after different screening strategies was simulated, with a cycle of one year. The model parameters included epidemiological data, clinical efficacy, cost and effectiveness. The total cost of treatment and quality\u2010adjusted life year (QALY) were simulated to conduct a cost\u2010effectiveness analysis. Univariate and probabilistic sensitivity analyses of the model were also performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PA screening patients with high\u2010risk hypertension and all patients with hypertension obtained 15.75 and 15.77 QALYs and the costs were $2488.39 and $2482.15, respectively. The strategy of PA screening in all patients with hypertension is cost\u2010saving and produces more health outcomes. The sensitivity analysis showed that the results were reliable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>From the perspective of China's health system, the strategy of screening all hypertensive patients for PA may be more cost\u2010effective than screening only high\u2010risk patients and providing standard antihypertensive treatment for low\u2010risk hypertensive patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14478","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T08:00:44Z","timestamp":1618041644000},"page":"414-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cost\u2010effectiveness analysis of screening for primary aldosteronism in China"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5529-0127","authenticated-orcid":false,"given":"Na","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingze","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maobai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fujian Medical University Union Hospital  Fuzhou China"},{"name":"The School of Pharmacy Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0352-3865","authenticated-orcid":false,"given":"Libin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Medical University Union Hospital  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11911-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032380"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.7326\/M20-0065"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.02.052"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328360ddf6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30319-4"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.05.085"},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Revision committee of the guidelines for the prevention and treatment of hypertension in China. 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