{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T14:45:32Z","timestamp":1766760332650,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873641","82070817"],"award-info":[{"award-number":["81873641","82070817"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Bone responsiveness to parathyroid hormone (PTH) in different subtypes of pseudohypoparathyroidism type 1 (PHP1) remains controversial. We aimed to investigate this phenomenon using bone turnover markers (BTMs) in a large cohort of PHP1 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Sixty\u2010three PHP1 patients diagnosed by molecular analysis were used as subjects, and 48 sex\u2010 and age\u2010matched patients with nonsurgical hypoparathyroidism (NS\u2010HP) were used for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Bone turnover markers, alkaline phosphatase (ALP), C\u2010terminal telopeptide of type I collagen (\u03b2\u2010CTX) and related parameters in PHP1 were compared among different subtypes and with NS\u2010HP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among all the PHP1 patients (15 PHP1A, 14 familial 1B and 34 sporadic 1B), 23.8% had elevated baseline BTM levels. No significant difference was found in the \u03b2\u2010CTX levels among different subtypes. The \u03b2\u2010CTX level was positively correlated with the PTH level for all PHP1, PHP1B and PHP1A patients (B\u00a0=\u00a00.001, 0.001 and 0.004, respectively; all <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). The BTM levels of PHP1 patients were significantly higher than those of NS\u2010HP patients (\u03b2\u2010CTX: 0.56\u00a0ng\/ml vs. 0.20\u00a0ng\/ml, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001; ALP: 105 U\/L vs. 72 U\/L, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001). The serum \u03b2\u2010CTX levels in different PHP1 subtypes were all significantly higher than those in NS\u2010HP patients in adults. Among the 22 followed up patients, changes in BTMs were associated with changes in PTH (\u03b2\u2010CTX: <jats:italic>r<\/jats:italic>\u00a0=\u00a0.507, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.023; ALP: <jats:italic>r<\/jats:italic>\u00a0=\u00a0.475, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.034).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Bone tissues respond to PTH in different PHP1 subtypes, and it is reasonable to monitor and normalize PTH and BTMs in addition to the serum and urinary calcium levels in the follow\u2010up of PHP1 patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14496","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T01:40:25Z","timestamp":1620524425000},"page":"277-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone turnover markers are associated with the PTH levels in different subtypes of 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Health Commission Department of Endocrinology Peking Union Medical College Hospital (PUMCH) Chinese Academy of Medical Sciences (CAMS) Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6837-7101","authenticated-orcid":false,"given":"Tingting","family":"Quan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Endocrinology of National Health Commission Department of Endocrinology Peking Union Medical College Hospital (PUMCH) Chinese Academy of Medical Sciences (CAMS) Beijing China"},{"name":"Department of Radiology Sun Yat\u2010sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenmin","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Radiology Peking Union Medical College Hospital (PUMCH) Chinese Academy of Medical Sciences 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