{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T04:43:39Z","timestamp":1772772219187,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T00:00:00Z","timestamp":1622332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Low bone mineral density (BMD) is a frequent and invalidating consequence of chronic undernourishment in patients with anorexia nervosa (AN). The aim of this study was to assess prevalence and clinic\u2010biological correlates of low BMD and fractures in extremely undernourished inpatients with AN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective cohort study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and measurements<\/jats:title><jats:p>This study included 97 extremely malnourished female inpatients with AN consecutively admitted over 2\u00a0years. Clinical\u2010biological variables, history of fractures and BMD by dual\u2010energy X\u2010ray absorptiometry (DXA) were examined to find predictors of low BMD and fractures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of low BMD was of 51% for lumbar spine and 38% for femoral neck. Z\u2010scores were lower at lumbar spine (\u22122.2\u00a0\u00b1\u00a01.2 SD) than at femoral neck (\u22121.9\u00a0\u00b1\u00a00.9 SD) (<jats:italic>P<\/jats:italic>&lt;.01). Fragility fractures were reported by 10% of patients. BMD was mainly predicted by FFM, illness duration, age at onset and restricting AN (<jats:italic>P<\/jats:italic>&lt;.05). Fractures were predicted by sodium concentrations, femoral neck Z\u2010score and illness duration (<jats:italic>P<\/jats:italic>&lt;.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Extremely severe patients with AN have high prevalence of low BMD, predicted by severity and chronicity of malnutrition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14498","type":"journal-article","created":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T06:24:36Z","timestamp":1620887076000},"page":"423-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bone mineral density at extremely low weight in patients with anorexia nervosa"],"prefix":"10.1111","volume":"95","author":[{"given":"Pauline","family":"Bemer","sequence":"first","affiliation":[{"name":"Clinical Nutrition unit Paul Brousse University Hospital (AP\u2010HP) Villejuif 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