{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T18:20:20Z","timestamp":1784312420843,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to describe rates and characteristics of non\u2010elective 30\u2010day readmission among patients hospitalized for adrenal insufficiency and to assess predictors of readmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>We analysed the 2018 National Readmission Database. Adrenal insufficiency hospitalizations were identified using the International Classification of Diseases, Tenth Revisions, Clinical Modification diagnosis codes for principal diagnostic codes of primary adrenal insufficiency, Addisonian crisis, drug\u2010induced adrenocortical insufficiency, and other and unspecified adrenocortical insufficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>During the study period, 7738 index hospitalizations were identified as patients with AI who met the inclusion criteria. Of these, 7691 were discharged alive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>We utilized chi\u2010squared tests to compare baseline characteristics between readmissions and index hospitalizations. Multivariate Cox regression was used to identify independent predictors of readmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 30\u2010day all\u2010cause readmission rate for AI was 17.3%. About 1 in 5 readmissions was for AI. Other reasons for readmission included sepsis (10.8%), unspecified pneumonia (3.1%) and acute renal failure unspecified (1.6%). Readmission was associated with significantly higher odds of inpatient mortality. Independent predictors of 30\u2010day all\u2010cause readmissions included index hospitalizations with the Charlson Comorbidity Index (CCI) \u22653 (adjusted hazards ratio (aHR): 2.53, 95% CI: 1.85\u20133.46,<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001), protein\u2010energy malnutrition (aHR: 1.28, 95% CI: 1.02\u20131.60,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035) and obesity (aHR: 1.26, 95% CI: 1.02\u20131.56,<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The 30\u2010day all\u2010cause readmission rate was 17.3%. AI was the most common reason for readmission among other causes. Readmissions were associated with increased mortality. CCIs of 3 or more, protein\u2010energy malnutrition and obesity were significant predictors of readmission.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14500","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T15:16:51Z","timestamp":1621091811000},"page":"269-276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of 30\u2010day readmissions for adrenal insufficiency: A retrospective national database study"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-8572","authenticated-orcid":false,"given":"Asim","family":"Kichloo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Central Michigan University Saginaw Michigan USA"},{"name":"Department of Medicine Samaritan Medical Center Watertown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7649-5634","authenticated-orcid":false,"given":"Zain","family":"El\u2010amir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Central Michigan University Saginaw Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9456-4581","authenticated-orcid":false,"given":"Hafeez","family":"Shaka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine John H. Stronger Jr. Hospital Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4683-6845","authenticated-orcid":false,"given":"Farah","family":"Wani","sequence":"additional","affiliation":[{"name":"Department of Medicine Samaritan Medical Center Watertown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Junaid","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Endocrinology South Shore University Hospital Bay Shore New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804635"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0469"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61684-0"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2221"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-19-0469"},{"key":"e_1_2_11_7_1","unstructured":"Overview of the Nationwide Readmissions Database (NRD) Healthcare Cost and Utilization Project. Accessed January 31 2021.https:\/\/www.hcup\u2010us.ahrq.gov\/nrdoverview.jsp"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181484347"},{"key":"e_1_2_11_9_1","unstructured":"Cost\u2010to\u2010Charge Ratio Files.Healthcare Cost and Utilization Project. Accessed January 31 2021.https:\/\/www.hcup\u2010us.ahrq.gov\/db\/ccr\/costtocharge.jsp"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12865"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0879"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0076"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"issue":"24","key":"e_1_2_11_14_1","first-page":"1740","article-title":"Adrenal Insufficiency","volume":"141","author":"Burger\u2010Stritt S","year":"2016","journal-title":"Deutsche medizinische Wochenschrift (1946)"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2012.11.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03340.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04006-X"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024459"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.08.097"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2011-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/509"},{"issue":"6","key":"e_1_2_11_22_1","first-page":"1175","article-title":"Malnutrition prevalence in adrenal insufficiency among hospitalized elderly patients: limitations of the body mass index in the assessment of malnutrition","volume":"27","author":"Lee SY","year":"2018","journal-title":"Asia Pac J Clin Nutr"},{"issue":"11","key":"e_1_2_11_23_1","doi-asserted-by":"crossref","first-page":"e018443","DOI":"10.1136\/bmjopen-2017-018443","article-title":"Malnutrition and its association with readmission and death within 7 days and 8\u2013180 days postdischarge in older patients: a prospective observational study","volume":"7","author":"Sharma Y","year":"2017","journal-title":"BMJ Open"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14500","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cen.14500","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.14500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:54:43Z","timestamp":1725058483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.14500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,3]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1111\/cen.14500"],"URL":"https:\/\/doi.org\/10.1111\/cen.14500","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,3]]},"assertion":[{"value":"2021-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}