{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T04:47:27Z","timestamp":1770353247493,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Tumour\u2010induced osteomalacia (TIO) is a rare paraneoplastic condition characterised by decreased tubular phosphate reabsorption. The purpose of this study is to evaluate bone mineral density (BMD) and microarchitecture in six TIO patients, compared with 18 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Volumetric BMD and microarchitecture were evaluated by high\u2010resolution peripheral quantitative computed tomography (HR\u2010pQCT), and areal BMD by dual\u2010energy X\u2010ray absorptiometry (DXA). Differences between groups were significant for <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All TIO subjects were healthy until the development of diffuse bone pain and multiple skeletal fractures and deformities. At baseline, sPi and TmPi\/GFR were low and patients were on vitamin D and phosphate replacement at the study. Compared with controls, TIO patients had lower aBMD at lumbar spine and hip, and lower vBMD at trabecular, cortical and entire bone, at distal radius (<jats:italic>R<\/jats:italic>) and distal tibia (<jats:italic>T<\/jats:italic>): trabecular vBMD (<jats:italic>R<\/jats:italic>\u2009=\u2009118.3\u2009\u00d7\u2009177.1; <jats:italic>T<\/jats:italic>\u2009=\u200972.3\u2009\u00d7\u2009161.3\u2009gHA\/cm<jats:sup>3<\/jats:sup>); cortical vBMD (<jats:italic>R<\/jats:italic>\u2009=\u2009782.3\u2009\u00d7\u2009866.5; <jats:italic>T<\/jats:italic>\u2009=\u2009789.1\u2009\u00d7\u2009900.9\u2009gHA\/cm<jats:sup>3<\/jats:sup>); total region vBMD (<jats:italic>R<\/jats:italic>\u2009=\u2009234.5\u2009\u00d7\u2009317; <jats:italic>T<\/jats:italic>\u2009=\u2009167.1\u2009\u00d7\u2009295.8\u2009gHA\/cm<jats:sup>3<\/jats:sup>). Bone microarchitecture was very heterogeneous among patients and significantly different from controls: lower cortical thickness (<jats:italic>R<\/jats:italic>\u2009=\u20090.59\u2009\u00d7\u20090.80; <jats:italic>T<\/jats:italic>\u2009=\u20090.90\u2009\u00d7\u20091.31\u2009mm), bone volume\u2010to\u2010total volume ratio (<jats:italic>R<\/jats:italic>\u2009=\u20090.09\u2009\u00d7\u20090.14; <jats:italic>T<\/jats:italic>\u2009=\u20090.06\u2009\u00d7\u20090.13) and Tb.N (<jats:italic>R<\/jats:italic>\u2009=\u20091.46\u2009\u00d7\u20092.10; <jats:italic>T<\/jats:italic>\u2009=\u20090.93\u2009\u00d7\u20091.96\u2009mm<jats:sup>\u22121<\/jats:sup>) and also higher Tb.Sp (<jats:italic>R<\/jats:italic>\u2009=\u20090.70\u2009\u00d7\u20090.41; <jats:italic>T<\/jats:italic>\u2009=\u20091.28\u2009\u00d7\u20090.45\u2009mm) and Tb.1\/N.SD\u00a0(<jats:italic>R<\/jats:italic>\u2009=\u20090.42\u2009\u00d7\u20090.18; <jats:italic>T<\/jats:italic>\u2009=\u20090.87\u2009\u00d7\u20090.20\u2009mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this original study of TIO patients, DXA and HR\u2010pQCT evaluation identified lower areal and volumetric BMD and severely impaired microarchitecture at cortical and trabecular bones, which probably contribute to bone fragility and fractures.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14533","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T17:25:19Z","timestamp":1622136319000},"page":"587-594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Microarchitectural parameters and bone mineral density in patients with tumour\u2010induced osteomalacia by HR\u2010pQCT and DXA"],"prefix":"10.1111","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5035-7564","authenticated-orcid":false,"given":"Danielle A. B.","family":"Mendes","sequence":"first","affiliation":[{"name":"Endocrinology Division Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-5604","authenticated-orcid":false,"given":"Maria C. A.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Endocrinology Division, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3552-0896","authenticated-orcid":false,"given":"B\u00e1rbara","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Endocrinology Division Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Endocrinology Division, Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Postgraduate Program in Clinical and Experimental Pathophysiology (FISCLINEX),\u00a0Faculty of Medical Sciences State University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1339-3192","authenticated-orcid":false,"given":"Leandro K. J.","family":"de Pinho","sequence":"additional","affiliation":[{"name":"Endocrinology Division Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-1090","authenticated-orcid":false,"given":"Luis F.","family":"Cardoso Lima","sequence":"additional","affiliation":[{"name":"Nuclear Engineering Program Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-0993","authenticated-orcid":false,"given":"Francisco","family":"Paranhos\u2010Neto","sequence":"additional","affiliation":[{"name":"Endocrinology Division Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2129-3546","authenticated-orcid":false,"given":"Laura M. C.","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[{"name":"Rheumatology Division Federal University of Rio de Janeiro  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0466-3250","authenticated-orcid":false,"given":"M. L. 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