{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:40:54Z","timestamp":1792176054371,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2\u00a0through angiotensin\u2010converting enzyme 2 receptor can harm testes function. The objectives were to analyse the prevalence of low serum testosterone (LT) and impaired fertility potential (Leydig and Sertoli cells dysfunction, respectively) in coronavirus disease 2019 (COVID\u201019) male survivors and to evaluate acute infection\u2010related associated factors. Also, we explore its association with post\u2010acute COVID\u201019 syndrome (PCS) and quality of life (QOL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Male adults recovered from polymerase chain reaction\u2010confirmed COVID\u201019 were offered a structured evaluation 8\u201312 weeks after recovery. The main outcome measure(s) were as follows: LT, defined as total testosterone (TT)\u2009&lt;\u20092\u2009ng\/ml or if TT levels 2\u20134\u2009ng\/ml as calculated free testosterone\u2009&lt;\u20096.36\u2009ng\/dl; Sertoli cell dysfunction was defined as inhibin\u2010B\u2009&lt;\u200989\u2009pg\/ml. Secondary outcome\u2010associated factors were analysed by multiple logistic regression (odds ratio; 95% confidence interval [CI]). QOL was evaluated by SF\u201036 v.2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and forty\u2010three patients were evaluated at a median (interquartile range) of 77 days (72\u201383) after disease onset; 72% of them recovered from severe pneumonia. LT was detected in 41 patients (28.7%; 95% CI: 21.8\u201336.5). Low levels of inhibin\u2010B were detected in 25 patients (18.1%; 95% CI: 12.5\u201325.3). After multivariate adjustment, obesity and hypokalaemia were associated with LT, whereas age more than 65 was an independent predictor of Sertoli cell dysfunction. LT or Sertoli cell dysfunction was not associated with PCS. Patients with LT had a lower score in four domains of QOL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence of male LT and impaired fertility potential in COVID\u201019 survivors is high in the medium term. Traditional risk factors and severity markers for COVID\u201019 could be predictive.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.14537","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T15:22:15Z","timestamp":1624461735000},"page":"353-362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Male pituitary\u2013gonadal axis dysfunction in post\u2010acute COVID\u201019 syndrome\u2014Prevalence and associated factors: A Mediterranean case series"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8670-6404","authenticated-orcid":false,"given":"Oscar","family":"Moreno\u2010Perez","sequence":"first","affiliation":[{"name":"Endocrinology and Nutrition Department Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"},{"name":"Clinical Medicine Department Miguel Hern\u00e1ndez University Elche 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Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0219-9055","authenticated-orcid":false,"given":"Mariano","family":"Andres","sequence":"additional","affiliation":[{"name":"Clinical Medicine Department Miguel Hern\u00e1ndez University Elche Spain"},{"name":"Rheumatology Department Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7922-5664","authenticated-orcid":false,"given":"Jose\u2010Manuel","family":"Leon\u2010Ramirez","sequence":"additional","affiliation":[{"name":"Pneumology Department Alicante General University Hospital, Alicante Institute of Health and Biomedical Research (ISABIAL) Alicante 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